133377-41-0

Upstream product

• 24127-62-6 methyl 2-bromo-3-phenylacrylate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 591-50-4 iodobenzene 
• 382-90-1 methyl α-trifluoromethylacrylate 
• 2926-29-6 Langlois reagent 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 24127-62-6 methyl (E)-2-bromo-3-phenylprop-2-enoate 
• 371-76-6 bis(trifluoromethyl)mercury 
• 21788-36-3 (Z)-methyl 2-bromo-3-phenylacrylate 
• 100-52-7 benzaldehyde 
• 173558-71-9 2-diazo-3,3,3-trifluoropropionic acid methyl ester 

Relevant academic research and scientific papers

Copper-Catalyzed Synthesis of α-Trifluoromethylacrylates from Trifluoroborylacrylates via Stereoretentive Radical Trifluoromethylation

We report the synthesis of α-trifluoromethylacrylates from α-trifluoroborylacrylates via a stereoretentive radical trifluoromethylation with inexpensive reagents NaSO2CF3 and TBHP at room temperature. Under these conditions, a wide substrate scope afforded the (E)-diastereomer exclusively in moderate to good yield. The utility of the reaction products is demonstrated in the synthesis of phenyl-4H-pyran, a potent and selective class of IKCa channel blockers. (Figure presented.).

Ligand-free palladium-catalyzed Mizoroki-Heck reaction to synthesize valuable α-trifluoromethylacrylates

α-Trifluoromethylacrylates were synthesized using efficient ligand-free palladium catalyzed Mizoroki-Heck reaction. With the alkyl trifluoromethylacrylates used as substrates, different catalytic systems were explored including Pd/C as a catalyst. Good to excellent yields were obtained with good chemical tolerance.

Synthesis of α-Trifluoromethylacrylates by Ligand-Free Palladium-Catalyzed Mizoroki-Heck Reaction

Efficient ligand-free palladium catalyzed Mizoroki-Heck reaction allowed the formation of trisubstituted α-trifluoromethylacrylates. The reaction showed good chemical tolerance and furnished moderate to excellent yields of reaction. Silver salt additive proved to be essential for the reaction. The reaction has been then applied to the formation of 3-trifluoromethyl coumarins and analogues of therapeutic agents.

A synthetic three fluoro methyl acrylic acid derivative method

The invention relates to a novel method for synthesizing a derivative of trifluoromethyl acrylic acid. In the method, a target product with yield of more than 80% can be obtained with commercial trifluoropropionic acid (or esters thereof) and aldehyde as

Efficient trifluoromethylation of activated and non-activated alkenyl halides by using (trifluoromethyl)trimethylsilane

An efficient method for the trifluoromethylation of halogenated double bonds by using in situ generated "trifluoromethyl copper" is described. Herein, the most common trifluoromethyl source, (trifluoromethyl) trimethylsilane, was converted selectively int

Trifluoromethylation of alkenyl bromides and iodides (including 5-iodouracils) with (CF3)2Hg and Cu (" trifluoromethylcopper")

Bromo- and iodoalkenes undergo trifluoromethylation efficiently in DMA with "CF3Cu" generated from (CF3)2Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retention.

Transition metal-catalyzed formation of CF3-substituted α,β-unsaturated alkene and the synthesis of α-trifluoromethyl substituted β-amino ester

A new transition metal-catalyzed formation of CF3-substituted α,β-unsaturated alkenes through the ylide intermediate from the reaction between methyl 3,3,3-trifluoro-2-diazopropionate 1 and aryl aldehydes has been developed. Further transformation of the alkene affords the α-trifluoromethyl substituted β-amino ester, a valuable intermediate in the synthesis of fluorine-containing amino acids with potential biological application.