133436-18-7

Upstream product

• 858788-75-7 2-(4-chlorophenyl)-5-methyl-1H-indole 
• 106-39-8 bromochlorobenzene 
• 205756-30-5 2-amino-N-methoxy-N,5-dimethylbenzamide 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 4692-99-3 6-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 
• 212200-93-6 N,N'-Bis(4-tolyl)terephthalimidoyl dichloride 
• 36360-33-5 Terephthalsaeure-bis-(p-toluidid) 
• 16687-61-9 5-(4-chlorophenyl)-1H-tetrazole 

Downstream Products

• 1449372-92-2 3-acetyl-4-(4-chlorophenyl)-6-methylquinolin-2(1H)-one 
• 1449373-73-2 4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]-6-methylquinolin-2(1H)-one 
• 1449374-18-8 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobutanoic acid 
• 1449373-28-7 (E)-4-(4-chlorophenyl)-3-[3-(4-chlorophenyl)acryloyl]-6-methylquinolin-2(1H)-one 
• 83388-25-4 Sodium; [2-amino-3-(4-chloro-benzoyl)-5-methyl-phenyl]-acetate 
• 91714-10-2 7-(4-Chloro-benzoyl)-5-methyl-3-methylsulfanyl-1,3-dihydro-indol-2-one 
• 91714-11-3 7-(4-Chloro-benzoyl)-5-methyl-1,3-dihydro-indol-2-one 

Relevant academic research and scientific papers

2-Arylindoles: A new entry to transition metal-free synthesis of 2-aminobenzophenones

Various 2-aminobenzophenones were synthesized from readily available 2-arylindoles in DMSO under O2 balloon atmosphere. The synthesis was carried out without the aid of a transition metal catalyst or moisture-sensitive organometallic reagents from 2-arylindoles.

Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists

Here we describe the synthesis and structure-activity relationship for a class of pyrazoline-containing dihydroquinolone negative allosteric modulators of the NMDA receptor that show strong subunit selectivity for GluN2C- and GluN2D-containing receptors over GluN2A- and GluN2B-containing receptors. Several members of this class inhibit NMDA receptor responses in the nanomolar range and are more than 50-fold selective over GluN1/GluN2A and GluN1/GluN2B NMDA receptors, as well as AMPA, kainate, GABA, glycine, nicotinic, serotonin, and purinergic receptors. Analysis of the purified enantiomers of one of the more potent and selective compounds shows that the S-enantiomer is both more potent and more selective than the R-enantiomer. The S-enantiomer had an IC 50 of 0.17-0.22 μM at GluN2D- and GluN2C-containing receptors, respectively, and showed over 70-fold selectivity over other NMDA receptor subunits. The subunit selectivity of this class of compounds should be useful in defining the role of GluN2C- and GluN2D-containing receptors in specific brain circuits in both physiological and pathophysiological conditions.

Tetrazoles: XXXV. Synthesis of 3H-1,3,4-Benzotriazepines from 5-Aryltetrazoles

Reaction of 5-aryltetrazoles with N,N′-bis(p-tolyl)terephthalimidoyl dichloride under conditions of phase-transfer catalysis yields isomeric N-imidoyltetrazoles whose thermolysis results in formation of 3H-1,3,4-benzotriazepines. The latter are hydrolyzed by the action of hydrochloric acid to afford terephthalic acid and the corresponding aminobenzophenone.