858788-75-7

Basic information

• Product Name: 1H-Indole, 2-(4-chlorophenyl)-5-methyl-
• CAS NO: 858788-75-7
• Molecular Formula: C15H12ClN
• Molecular Weight: 241.72
• Mol File: 858788-75-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2-(4-chlorophenyl)-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2-(4-chlorophenyl)-5-methyl-(858788-75-7)
• EPA Substance Registry System: 1H-Indole, 2-(4-chlorophenyl)-5-methyl-(858788-75-7)

Safety Data

• Hazardous Substances Data: 858788-75-7(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 539-44-6 N-4-methylphenylhydrazine 
• 33984-97-3 2,3-epoxy-3-(4-chlorophenyl)propanenitrile 
• 106-49-0 p-toluidine 
• 937-20-2 p-chlorophenacyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 33984-97-3 cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile 
• 2788-86-5 4-Chlorostyrene oxide 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 60532-55-0 1-(4-chloro-phenyl)-2-p-toluidino-ethanone 

Downstream Products

• 133436-18-7 (2-amino-5-methylphenyl)(4-chlorophenyl)methanone 

Relevant articles and documents

Palladium-Catalyzed C–C Ring Closure in α-Chloromethylimines: Synthesis of 1H-Indoles

The C-C ring closure of α-chloromethyl alkyl or aryl N-aryl imines catalyzed with 1 to 10 % Pd(OAc)2/P(p-tolyl)3 afford efficiently 2-aryl- and 2-alkyl-1H-indoles. The heterocyclization reaction involves the initial formation of [2-(arylimino)ethyl]palladium(II) chloride complexes with subsequent C-H activation of the aromatic amine ring. Readily or commercially available α-chloromethyl-aryl or -alkyl ketones are used as the precursors. Functionalized indoles at the benzene ring are obtained when the imines are derived from substituted anilines.

Preparation method of indole compounds

The invention provides a preparation method of indole compounds. 2-cyanoethylene oxide compounds and arylamine react under the catalysis effect of lewis acid (boron trifluoride diethyl etherate or aluminum trichloride) to obtain corresponding indole compo

Ruthenium-catalyzed synthesis of indoles from anilines and epoxides

A general synthetic route to indoles from readily available anilines and epoxides by using ruthenium catalysis is described. This straightforward transformation allows a variety of indoles to be obtained in good yields by using [Ru3(CO)12]/1,1-bis(diphenylphosphino)ferrocene as the catalytic system. Water and hydrogen are formed as the only stoichiometric by-products, making this process highly atom efficient.