205756-30-5

Usage

General Description

2-amino-N-methoxy-N,5-dimethylBenzamide is a chemical compound with the molecular formula C11H16N2O2. It is a benzamide derivative with a methyl group attached to the 5th position of the benzene ring, as well as an amino and methoxy group attached to the nitrogen atom. 2-amino-N-methoxy-N,5-dimethylBenzamide has potential applications in pharmaceutical research and drug development due to its structural features and potential pharmacological properties. It may be of interest for its potential as a drug candidate or as a chemical building block for the synthesis of other compounds. Further studies and research are needed to fully understand the properties and potential uses of this chemical.

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 4692-99-3 6-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 

Downstream Products

• 133436-18-7 (2-amino-5-methylphenyl)(4-chlorophenyl)methanone 
• 1449372-75-1 (2-amino-5-methylphenyl)(3-fluorophenyl)methanone 
• 1449373-73-2 4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]-6-methylquinolin-2(1H)-one 
• 1449373-74-3 3[(5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)]-4-(3-fluorophenyl)-6-methylquinolin-2(1H)-one 
• 1449374-18-8 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobutanoic acid 
• 1449374-19-9 4-{5-(4-chlorophenyl)-3-[4-(3-fluorophenyl)-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobutanoic acid 
• 1449372-92-2 3-acetyl-4-(4-chlorophenyl)-6-methylquinolin-2(1H)-one 
• 1449372-93-3 3-acetyl-4-(3-fluorophenyl)-6-methylquinolin-2(1H)-one 
• 1449373-28-7 (E)-4-(4-chlorophenyl)-3-[3-(4-chlorophenyl)acryloyl]-6-methylquinolin-2(1H)-one 
• 1449373-29-8 (E)-3-[3-(4-chlorophenyl)acryloyl]-4-(3-fluorophenyl)-6-methylquinolin-2(1H)-one 
• 17852-28-7 2-amino-5-methylbenzophenone 
• 52107-75-2 6-Iod-3-methylbenzophenon 

Relevant academic research and scientific papers

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.

Rapid construction of cyclopenta[: B] naphthalene frameworks from propargylic alcohol tethered methylenecyclopropanes

We have developed a new synthetic methodology for the rapid construction of cyclopenta[b]naphthalene frameworks from the reaction of propargylic alcohol tethered methylenecyclopropanes with mesyl chloride in the presence of triethylamine through cascade cyclization. The reaction can be performed under mild conditions without the use of transition metals, affording the target products in moderate to good yields, and this cyclization reaction process can be scaled up to a gram-scale synthesis.

GLUN2C/D SUBUNIT SELECTIVE ANTAGONISTS OF THE N-METHYL-D-ASPARTATE RECEPTOR

A compound according to Formula (I) or salts or prodrugs thereof and pharmaceutical formulations comprising the compound are provided herein for the treatment of neurological disorders. The disorders may include providing neuroprotection, preventing neurodegeneration, treating neuropathic pain or treating schizophrenia, psychoses or depression. Furthermore, the compounds may be used in combination with another active ingredient.

Synthesis of Diiodinated All-Carbon 3,3′-Diphenyl-1,1′-spirobiindene Derivatives via Cascade Enyne Cyclization and Electrophilic Aromatic Substitution

A synthetic method for the construction of diiodinated all-carbon spirobiindene derivatives has been developed from the reaction of propargyl alcohol-tethered alkylidenecyclopropanes with iodine. The reaction proceeded through an iodination-initiated cascade intramolecular enyne cyclization and electrophilic aromatic substitution reaction process in 1,2-dichloroethane upon heating, giving desired spirocyclic products in moderate to excellent yields. Further transformation of the obtained products has also been presented.

Lewis or Br?nsted acid-catalysed reaction of propargylic alcohol-tethered alkylidenecyclopropanes with indoles and pyrroles for the preparation of polycyclic compounds tethered with indole or pyrrole motif

We developed a facile synthetic method to access cyclopenta[b]naphthalene derivatives via the Lewis or Br?nsted acid catalysed cascade nucleophilic addition, electronic cyclization, ring-opening rearrangement of propargylic alcohol-tethered alkylidenecyclopropanes with indole and pyrrole derivatives. The reaction exhibited a broad substrate scope and good functional group tolerance under metal-free conditions, affording the desired products in moderate to good yields.

Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists

Here we describe the synthesis and structure-activity relationship for a class of pyrazoline-containing dihydroquinolone negative allosteric modulators of the NMDA receptor that show strong subunit selectivity for GluN2C- and GluN2D-containing receptors over GluN2A- and GluN2B-containing receptors. Several members of this class inhibit NMDA receptor responses in the nanomolar range and are more than 50-fold selective over GluN1/GluN2A and GluN1/GluN2B NMDA receptors, as well as AMPA, kainate, GABA, glycine, nicotinic, serotonin, and purinergic receptors. Analysis of the purified enantiomers of one of the more potent and selective compounds shows that the S-enantiomer is both more potent and more selective than the R-enantiomer. The S-enantiomer had an IC 50 of 0.17-0.22 μM at GluN2D- and GluN2C-containing receptors, respectively, and showed over 70-fold selectivity over other NMDA receptor subunits. The subunit selectivity of this class of compounds should be useful in defining the role of GluN2C- and GluN2D-containing receptors in specific brain circuits in both physiological and pathophysiological conditions.