13345-25-0

Basic information

• Product Name: benzo(a)pyrene 7,8-dihydrodiol
• Synonyms: benzo(a)pyrene 7,8-dihydrodiol;7,8-DIHDYROXY-7,8-DIHYDROBENZO(A)PYRENE;BENZO[A]PYRENE-TRANS-7,8-DIHYDRODIOL;B[a]P-7,8-diol;Benzopyrene Related Compound 11
• CAS NO: 13345-25-0
• Molecular Formula: C20H14O2
• Molecular Weight: 286.34
• Mol File: 13345-25-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 553.3°Cat760mmHg
• Flash Point: 268.6°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 4.47E-13mmHg at 25°C
• Refractive Index: 1.911
• CAS DataBase Reference: benzo(a)pyrene 7,8-dihydrodiol(CAS DataBase Reference)
• NIST Chemistry Reference: benzo(a)pyrene 7,8-dihydrodiol(13345-25-0)
• EPA Substance Registry System: benzo(a)pyrene 7,8-dihydrodiol(13345-25-0)

Safety Data

• Hazardous Substances Data: 13345-25-0(Hazardous Substances Data)

Usage

Safety Profile

Questionable carcinogen withexperimental neoplastigenic and tumorigenic data. Humanmutation data reported. When heated to decomposition itemits acrid smoke and irritating fumes.

InChI:InChI=1/C20H14O2/c21-17-9-8-14-15-7-6-12-3-1-2-11-4-5-13(19(15)18(11)12)10-16(14)20(17)22/h1-10,17,20-22H

Upstream product

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• 16932-45-9 1-bromo-2,6-dimethoxybenzene 
• 19821-80-8 1,3-dibromo-2-iodo-benzene 
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• 57405-01-3 C₃₄H₂₃BrO₄ 
• 57405-00-2 (+/-)-7,8,9,10-Tetrahydrobenzopyrene-trans-7,8-diol dibenzoate 
• 6272-55-5 7-hydroxy-7,8,9,10-tetrahydrobenzopyrene 
• 17573-15-8 9,10-dihydro benzopyrene 
• 678996-94-6 2-(2,6-bis{2-methoxyvinyl}phenyl)-6-methoxynaphthalene 
• 671780-70-4 2-methoxy-6-(2,6-divinylphenyl)naphthalene 
• 671780-69-1 2-(2-methoxynaphthalen-6-yl)benzene-1,3-dialdehyde 
• 17573-31-8 3-methoxybenzopyrene 
• 13345-26-1 7-hydroxy benzopyrene 

Downstream Products

• 63323-30-8 (+/-)-r-7,t-8-Dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene 
• 60864-95-1 (-)-7R-trans-Benzopyrene-7,8-dihydrodiol 
• 62314-67-4 (+/-)-trans-7,8-Dihydrobenzo[a]pyrene-7,8-diol 
• 61490-66-2 7,8,9,10-tetrahydroxytetrahydrobenzopyrene 
• 58917-91-2 (+/-)-7α,8β-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene 
• 62697-16-9 (+/-)-7β,8α,9α,10α-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene 
• 62697-17-0 r-7,t-8,10,c-9-tetrahydroxy-7,8,9,10-tetrahydrobenzopyrene 
• 62697-13-6 (+/-)-7β,8α,9β,10β-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene 
• 37994-82-4 7-Hydroxybenzo[a]pyrene 
• 13345-26-1 7-hydroxy benzopyrene 

Relevant articles and documents

Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7,8- dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase

Recombinant human enzymes expressed in membranes obtained from Escherichia coli transformed with cytochrome P450 (P450) and NADPH-P450 reductase cDNAs were used to identify the human P450 enzymes that are most active in catalyzing the oxidative transformation of benzo[a]pyrene in vitro. Activation of benzo[a]pyrene to genotoxic products that cause induction of umu gene expression in Salmonella typhimurium NM2009 by P450 1A1 and P450 1B1 enzymes was found to be enhanced by inclusion of purified epoxide hydrolase (isolated from rat or human livers) with the reaction mixture. High- performance liquid chromatographic analysis showed that P450 1B1 catalyzed benzo[a]pyrene to trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene at level of ~3 nmol min-1 nmol of P450-1 only when epoxide hydrolase was present and P450 1A1 (with the hydrolase) was able to catalyze benzo[a]pyrene at one- tenth of the activity catalyzed by P450 1B1. Kinetic analysis showed that ratio of V(max) to K(m) for the formation of trans-7,8-dihydroxy-7,8- dihydrobenzo[a]pyrene in this assay system was 3.2-fold higher in CYP1B1 than in CYP1A1. Other human P450s (including P450s 1A2, 2E1, and 3A4) were found to have very low or undetectable activities toward the formation of trans- 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene. A reconstituted system containing purified P450 1B1, rabbit liver NADPH-P450 reductase, and human liver epoxide hydrolase was found to catalyze benzo[a]pyrene to trans-7,8-dihydroxy-7,8- dihydrobenzo[a]pyrene at a rate of 0.86 nmol min-1 nmol of P450-1; the activities were found to be largely dependent on the presence of sodium cholate in the system. These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy- 7,8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]-pyrene carcinogenesis.

Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis

A diastereoselective synthesis of the nucleoside adducts corresponding to a cis ring-opening of the carcinogen (±)-7β,8α-dihydroxy- 9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP DE-2) by 2′-deoxyadenosine and 2′-deoxyguanosine is described. The key

Efficient Synthesis of Non-K-Region trans-Dihydro Diols of Polycyclic Aromatic Hydrocarbons from o-Quinones and Catechols

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