1334513-09-5

Basic information

• Product Name: (S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate
• Synonyms: (S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate
• CAS NO: 1334513-09-5
• Molecular Weight: 576.546
• Mol File: 1334513-09-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate(1334513-09-5)
• EPA Substance Registry System: (S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate(1334513-09-5)

Safety Data

• Hazardous Substances Data: 1334513-09-5(Hazardous Substances Data)

Upstream product

• 108-95-2 phenol 
• 39613-92-8 alanine isopropyl ester hydrochloride 
• 770-12-7 O-phenyl phosphorodichloridate 
• 793-10-2 p-nitrophenyl phenyl phosphorochloridate 
• 1334513-02-8 (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester 
• 362-75-4 2',3'-isopropylidene adenosine 
• 1334513-00-6 (S)-2-[(S)-(2,4-dinitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester 
• 1256490-31-9 (S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester 
• 1334513-08-4 (2S)-isopropyl 2-(((2,4-dichlorophenoxy)(phenoxy)phosphoryl)amino)propanoate 
• 1256490-48-8 (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester 
• 1334513-07-3 (2S)-isopropyl 2-(((2-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate 
• 1334513-04-0 (S)-2-[(S)-(2-chloro-4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester 

Relevant articles and documents

Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189

A general and efficient method for the synthesis of pronucleotide (ProTide) 5'-phosphoramidate monoesters is reported. This method consists of a highly stereoselective 5'-phosphorylation mediated by dimethylaluminum chloride to afford the desired target ProTides in excellent yields without employing 3'-protection strategies. The application of this methodology to the synthesis of a number of pharmaceutically relevant compounds currently marketed or under investigation in clinical research is demonstrated.