133455-15-9Relevant academic research and scientific papers
Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues
Saha, Sanjay,Reddy, Ch. Venkata Ramana,Xu, Shili,Sankar, Saranya,Neamati, Nouri,Patro, Balaram
, p. 5135 - 5139 (2013/09/12)
The synthesis of several analogues of ma'edamines A and B are reported. The synthesized compounds were tested on hormone receptor positive and HER2 positive breast cancer cell lines, by MTT assay. MED-114, 115, 117, 119, 120, 124, 128 and 131 were found to be equally active as Lapatinib on HER2 +ve cell line SKBR3.
The first total synthesis and biological evaluation of marine natural products ma'edamines A and B
Saha, Sanjay,Venkata Ramana Reddy, Ch.,Chiranjeevi,Addepally, Uma,Chinta Rao,Patro, Balaram
, p. 1013 - 1016 (2013/03/13)
We have developed the first total syntheses of marine natural products ma'edamines A (18) and B (20). Structurally, they contain a pyrazine-2-(1H)-one core and were screened for antiproliferative activity on several cancer cell lines. Out of the six cell lines tested, ma'edamines A and B showed significant cytotoxicity against human colon cancer line COLO 205 (IC50 7.9 and 10.3 μM, respectively), breast cancer cell line MCF-7 (IC50: 6.9 and 10.5 μM, respectively) and human lung adenocarcinoma cell line A549 (IC50: 12.2 and 15.4 μM, respectively). The apoptotic effect of ma'edamines was confirmed by comet assay. Hence ma'edamines are likely to be useful as leads for development of a new class of anti-cancer agents.
The first total synthesis of racemic Hydroxymoloka'iamine
Ullah, Nisar
experimental part, p. 879 - 882 (2009/12/01)
The first total synthesis of racemic hydroxymoloka'iamine, a new brominated metabolite isolated from Red Sea sponge Pseudoceratna arabica, was achieved in a high-yield reaction sequence.
3-(heteroaryl)-1-?(2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1-?(2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
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, (2008/06/13)
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.
1-(arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-4-(heteroaryl) piperidines and related compounds useful as antipsychotics and analgesics
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, (2008/06/13)
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.
Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
-
, (2008/06/13)
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.
