1422285-83-3

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 1422285-82-2 C₂₆H₃₀Br₄N₂O₆ 
• 2887-72-1 1-(3,5-dibromo-4-hydroxyphenyl)ethan-1-one 
• 133455-15-9 1-[4-(3-bromopropoxy)-3,5-dibromophenyl]ethanone 
• 1202707-92-3 2-bromo-1-(3,5-dibromo-4-(3-bromopropoxy)phenyl)ethanone 
• 1422285-72-0 C₁₇H₂₂Br₃N₄O₂⁽¹⁺⁾*Br^(1-) 
• 1422285-74-2 C₁₁H₁₃Br₃NO₂⁽¹⁺⁾*Br^(1-) 
• 65623-98-5 1-[4-(3-bromopropoxy)phenyl]ethanone 

Relevant academic research and scientific papers

Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues

The synthesis of several analogues of ma'edamines A and B are reported. The synthesized compounds were tested on hormone receptor positive and HER2 positive breast cancer cell lines, by MTT assay. MED-114, 115, 117, 119, 120, 124, 128 and 131 were found to be equally active as Lapatinib on HER2 +ve cell line SKBR3.

The first total synthesis and biological evaluation of marine natural products ma'edamines A and B

We have developed the first total syntheses of marine natural products ma'edamines A (18) and B (20). Structurally, they contain a pyrazine-2-(1H)-one core and were screened for antiproliferative activity on several cancer cell lines. Out of the six cell lines tested, ma'edamines A and B showed significant cytotoxicity against human colon cancer line COLO 205 (IC50 7.9 and 10.3 μM, respectively), breast cancer cell line MCF-7 (IC50: 6.9 and 10.5 μM, respectively) and human lung adenocarcinoma cell line A549 (IC50: 12.2 and 15.4 μM, respectively). The apoptotic effect of ma'edamines was confirmed by comet assay. Hence ma'edamines are likely to be useful as leads for development of a new class of anti-cancer agents.