1422285-82-2Relevant articles and documents
Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues
Saha, Sanjay,Reddy, Ch. Venkata Ramana,Xu, Shili,Sankar, Saranya,Neamati, Nouri,Patro, Balaram
, p. 5135 - 5139 (2013/09/12)
The synthesis of several analogues of ma'edamines A and B are reported. The synthesized compounds were tested on hormone receptor positive and HER2 positive breast cancer cell lines, by MTT assay. MED-114, 115, 117, 119, 120, 124, 128 and 131 were found to be equally active as Lapatinib on HER2 +ve cell line SKBR3.