1422285-74-2Relevant academic research and scientific papers
Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues
Saha, Sanjay,Reddy, Ch. Venkata Ramana,Xu, Shili,Sankar, Saranya,Neamati, Nouri,Patro, Balaram
, p. 5135 - 5139 (2013/09/12)
The synthesis of several analogues of ma'edamines A and B are reported. The synthesized compounds were tested on hormone receptor positive and HER2 positive breast cancer cell lines, by MTT assay. MED-114, 115, 117, 119, 120, 124, 128 and 131 were found to be equally active as Lapatinib on HER2 +ve cell line SKBR3.
The first total synthesis and biological evaluation of marine natural products ma'edamines A and B
Saha, Sanjay,Venkata Ramana Reddy, Ch.,Chiranjeevi,Addepally, Uma,Chinta Rao,Patro, Balaram
, p. 1013 - 1016 (2013/03/13)
We have developed the first total syntheses of marine natural products ma'edamines A (18) and B (20). Structurally, they contain a pyrazine-2-(1H)-one core and were screened for antiproliferative activity on several cancer cell lines. Out of the six cell lines tested, ma'edamines A and B showed significant cytotoxicity against human colon cancer line COLO 205 (IC50 7.9 and 10.3 μM, respectively), breast cancer cell line MCF-7 (IC50: 6.9 and 10.5 μM, respectively) and human lung adenocarcinoma cell line A549 (IC50: 12.2 and 15.4 μM, respectively). The apoptotic effect of ma'edamines was confirmed by comet assay. Hence ma'edamines are likely to be useful as leads for development of a new class of anti-cancer agents.
