1334748-92-3Relevant academic research and scientific papers
Synthesis of 3-(o-stilbenyl)sydnone and 3-(o-stilbenyl)-4- substitutedsydnone derivatives and their antitumor evaluation
Butkovic, Kristina,Marinic, Zeljko,Sindler-Kulyka, Marija
, p. 1 - 15 (2011/09/16)
A series of novel stilbene-sydnone derivatives were synthesized by the following sequence of reactions: Starting from methyl anthranilate via glycine- and nitrosoglycine derivatives the corresponding 3-(o-carbomethoxyphenyl)-4-H/ Me/Ph-sydnones were prepared and transformed to 3-(o-formylphenyl)-4-H/Me/Ph- sydnones, starting materials for Wittig reaction with various phosphonium salts to stilbenylsydnone derivatives. Final products were evaluated for their cytotoxic properties on five cancer cell lines, whereby the cis-4-methyl-3-[2- [2-(4-methylphenyl)ethenyl]phenyl]sydnone 5 and cis-4-phenyl-3-[2-[2-(4- chlorophenyl)ethenyl]-phenyl]sydnone 10 showed the most pronounced activity. ARKAT-USA, Inc.
