64241-58-3Relevant academic research and scientific papers
Discovery of Fluorogenic Diarylsydnone-Alkene Photoligation: Conversion of ortho-Dual-Twisted Diarylsydnones into Planar Pyrazolines
Zhang, Linmeng,Zhang, Xiaocui,Yao, Zhuojun,Jiang, Shichao,Deng, Jiajie,Li, Bo,Yu, Zhipeng
supporting information, p. 7390 - 7394 (2018/06/13)
A small library of diarylsydnones (DASyds) was constructed based on aryl-pairing combinations and subjected to click reaction toward alkenes under photoirradiation with high efficiency. We were able to demonstrate the utility of DASyds for highly fluorescent turn-on ligation targeting the trans-cyclooct-4-en-1-ol moieties on protein.
Synthesis of 3-(o-stilbenyl)sydnone and 3-(o-stilbenyl)-4- substitutedsydnone derivatives and their antitumor evaluation
Butkovic, Kristina,Marinic, Zeljko,Sindler-Kulyka, Marija
, p. 1 - 15 (2011/09/16)
A series of novel stilbene-sydnone derivatives were synthesized by the following sequence of reactions: Starting from methyl anthranilate via glycine- and nitrosoglycine derivatives the corresponding 3-(o-carbomethoxyphenyl)-4-H/ Me/Ph-sydnones were prepared and transformed to 3-(o-formylphenyl)-4-H/Me/Ph- sydnones, starting materials for Wittig reaction with various phosphonium salts to stilbenylsydnone derivatives. Final products were evaluated for their cytotoxic properties on five cancer cell lines, whereby the cis-4-methyl-3-[2- [2-(4-methylphenyl)ethenyl]phenyl]sydnone 5 and cis-4-phenyl-3-[2-[2-(4- chlorophenyl)ethenyl]-phenyl]sydnone 10 showed the most pronounced activity. ARKAT-USA, Inc.
Activated carbonyl species for the preparation of ortho-acylarylsydnones
Turnbull, Kenneth,Beladakere, Ravindra N.,McCall, Neal D.
, p. 383 - 388 (2007/10/03)
ortho-Acylarylsydnones can be prepared in moderate to good yield by the action of nucleophiles upon suitable activated carbonyl species.
NEW CONVENIENT METHODS FOR THE SYNTHESIS OF 1,2-DIHYDRO-3H-INDAZOL-3-ONE AND ITS 1-ACYL DERIVATIVES
Dumitrascu, Florea,Plaveti, Marieta,Raileanu, Dan
, p. 917 - 924 (2007/10/03)
The acid hydrolysis of the readily obtainable 3-(o-carboxyphenyl)sydnones (6a-d) afforded 3-indazolones (3a-d) in yields over 90 percent. By transacylation between 1-acyl-3-acyloxyindazoles (11a-d) and 3-indazolones (3a, c), the corresponding 1-acyl-3-indazolones 10a-d resulted in pure state and yields also over 90 percent.
DEBROMINATION OF 4-BROMO-3-ARYLSYDNONES WITH SODIUM SULFITE
McChord, K. L.,Tullis, S. A.,Turnbull, K.
, p. 2249 - 2253 (2007/10/02)
4-Bromo-3-arylsydnones 1 are debrominated to the corresponding 3-arylsydnones 2 in good to excellent yield using sodium sulfite in methanol/water.In contrast to previously employed reagents, the reaction is successful in the presence of electron-donating,
The Efficient Synthesis of 3-Arylsydnones Under Neutral Conditions
Applegate, Jacqueline,Turnbull, Kenneth
, p. 1011 - 1012 (2007/10/02)
Various substituted aryl sydnones can be prepared in high yield under mild, neutral conditions by nitrosation of the appropriate aryl glycine with isoamyl nitrite in dimethoxyethane followed by cyclization with trifluoroacetic anhydride.
Debromination of 3-Aryl-4-bromosydnones with Sodium Borohydride
Turnbull, Kenneth
, p. 334 - 336 (2007/10/02)
Debromination of 4-bromo-3-(2-substituted aryl) sydnones 1 with sodium borohydride in methanol occurs readily to give good yields of the corresponding parent sydnones 2, except in those cases where the aryl substituent also reacts.The utility of the proce
DEBROMINATION OF 4-BROMO-3-ARYLSYDNONES WITH SODIUM DITHIONITE.
Turnbull, K.,Saljoughian, M.
, p. 461 - 466 (2007/10/02)
A variety of 4-bromo-3-arylsydnones can be debrominated with sodium dithionite in excellent yield under very mild conditions.
