1335040-07-7Relevant academic research and scientific papers
Combined heterogeneous metal/chiral amine: Multiple relay catalysis for versatile eco-friendly synthesis
Deiana, Luca,Jiang, Yan,Palo-Nieto, Carlos,Afewerki, Samson,Incerti-Pradillos, Celia A.,Verho, Oscar,Tai, Cheuk-Wai,Johnston, Eric V.,C?rdova, Armando
, p. 3447 - 3451 (2014/04/03)
Herein is described a versatile and broad synergistic strategy for expansion of chemical space and the synthesis of valuable molecules (e.g. carbocycles and heterocycles), with up to three quaternary stereocenters, in a highly enantioselective fashion from simple alcohols (31 examples, 95:5 to >99.5:0.5 e.r.) using integrated heterogeneous metal/chiral amine multiple relay catalysis and air/O2 as the terminal oxidant. A novel highly 1,4-selective heterogeneous metal/amine co-catalyzed hydrogenation of enals was also added to the relay catalysis sequences. Relay switch: A versatile strategy for expansion of chemical space and the synthesis of valuable molecules, having up to three quaternary stereocenters, in a highly enantioselective fashion from simple alcohols is described. The method employs integrated heterogeneous metal/chiral amine multiple relay catalysis and air/O2 as the terminal oxidant.
Dynamic one-pot three-component catalytic asymmetric transformation by combination of hydrogen-bond-donating and amine catalysts
Lin, Shuangzheng,Deiana, Luca,Zhao, Gui-Ling,Sun, Junliang,Cordova, Armando
, p. 7624 - 7630 (2011/10/09)
In control: The first dynamic one-pot three-component asymmetric transformation between aldehydes, protected α-cyanoglycine esters, and enals catalyzed by a combination of a simple hydrogen-bond-donating catalyst and a chiral amine catalyst is disclosed.
