133512-86-4

Upstream product

• 100-42-5 styrene 
• 536-74-3 phenylacetylene 
• 23680-39-9 2-bromo-1-fluoro-1-phenylethene 
• 886206-84-4 1,3-benzothiazol-2-yl (phenyl)fluoromethyl sulfone 
• 14371-10-9 (E)-3-phenylpropenal 
• 61378-39-0 (Z)-1-fluoro-2-iodo-1-phenylethylene 
• 66680-87-3 (E)-1-phenyl-(2-tributylstannyl)ethene 
• 67219-33-4 2-phenylmethanesulfonyl-benzothiazole 
• 28321-12-2 (E)-(4,4-difluorobuta-1,3-diene-1-yl)benzene 
• 104-55-2 3-phenyl-propenal 
• 19654-17-2 2-benzylthiobenzothiazole 
• 14156-61-7 2-<(phenylmethyl)sulfonyl>pyridine 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Stereoselective formation of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem?difluoroalkenes with lithium organoborates

A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem?difluoroalkenes in mild conditions was described. The combination of lithium organoborate and ZnBr2 generated in situ lithium ar

Reagent for preparing high-selectivity monofluoroolefin

The invention provides a reagent for preparing high-selectivity monofluoroolefin, particularly a reagent capable of preparing monofluoroolefin at high selectivity and a method for preparing monofluoroolefin by using the reagent. The method has the advanta

Spontaneous resolution of julia-kocienski intermediates facilitates phase separation to produce Z - And e -monofluoroalkenes

The monofluoroalkene motif is important in drug development as it serves as a peptide bond isostere and is found in a number of biologically active compounds with various pharmacological activities. Direct olefination of carbonyl compound is a straightfor

High-yield synthesis of fluorinated benzothiazolyl sulfones: General synthons for fluoro-Julia olefinations

General, high-yield tandem electrophilic fluorination and modified Julia olefination for the synthesis of fluoro olefins is reported. A series of α-fluoro 1,3-benzothiazol-2-yl sulfone-based synthons were synthesized via deprotonation-fluorination. Of critical importance for high-yield fluorinations were heterogeneous reaction conditions, as under homogeneous conditions only starting sulfones were recovered. The α-fluoro 1,3-benzothiazol-2-yl sulfones so obtained were subjected to condensations with a variety of aldehydes and ketones to afford high yields of regiospecifically fluorinated olefins.

Stereoselective synthesis of fluoroalkenes via (Z)-2-fluoroalkenyliodonium salts

Stereoselective synthesis of fluoroalkenes is described. (Z)-2-Fluoro-1-alkenyl(phenyl)iodonium tetrafluoroborates (1) were synthesized stereoselectively in good yields by Michael-type addition of HF to 1-alkynyl(phenyl)iodonium tetrafluoroborates (2) with a commercially available HF reagent, hydrofluoric acid or Et3N-3HF. Pd-catalyzed cross-coupling reactions using 1 gave (Z)-2-fluoro-1-alkene derivatives in moderate yields. The treatment of 1 with KI in the presence of a catalytic amount of CuI gave (Z)-2-fluoro-1-iodo-1-alkenes (3). Pd-catalyzed cross-coupling reactions of 3 gave better results than that of 1, and a variety of (Z)-2-fluoro-1-alkene derivatives were synthesized in good yields.

Regio- and Stereoselective Synthesis of Fluorinated Enynes and Dienes via 1,1- or 1,2-Halofluoroalkenes

Monofluorinated enynes and dienes were synthesized stereospecifically through palladium-catalyzed condensation of 1-halo-1-fluoroalkenes or 1-halo-2-fluoroalkenes with monosubstituted alkynes or alkenes, or with allyltributyltin.The various halofluoroalke

Synthesis of fluorinated enynes and dienes via 1-bromo 2-fluoro alkenes

A stereospecific synthesis of fluorinated enynes and dienes was performed through palladium-catalyzed condensation of 1-bromo-2-fluoroalkenes, synthesized either through 'BrF' addition to the corresponding alkynes or through bromine addition and HBr elimi