133549-39-0Relevant academic research and scientific papers
C,C-Coupling with sulfur-stabilized carbanions - 6. Preparation and electrophilic substitution of 1-[3-methyl-2-(2-thioanylthio)-butyl]piperidine and dethioacetalization of semicyclic dithioacetals
Birk, Claudia,Voss, Juergen
, p. 12745 - 12760 (1996)
1-[3-Methyl-2-(2-thioanylthio)butyl]piperidine (8) is obtained from L-valine via enantiomerically pure 1-(2-mercapto-3-methylbutyl)piperidine (6). The diastereoisomers are separated by column chromatography and the reactions of the carbanion 8a with elect
Biomimetic alloxan-catalyzed intramolecular redox reaction with O2: One-pot atom-economic synthesis of sulfinyl-functionalized benzimidazoles
Zhang, Shiqi,Yi, Dong,Li, Guangxun,Li, Ling,Zhao, Gang,Tang, Zhuo
supporting information, (2020/12/25)
Given the necessity of sacrificial reductants in various biomimetic aerobic oxygenations, alloxan-catalyzed aerobic redox system for one-pot atom-economic synthesis of sulfinyl-functionalized benzimidazoles was developed by ingeniously binding both the substrate sulfide and sacrificial reductant. This mild and transition-metal-free protocol undergoes two oxidations without additional sacrificial reagents, except for the environmentally benign molecular oxygen.
Building units for N-backbone cyclic peptides. Part 4. Synthesis of protected Nα-functionalized alkyl amino acids by reductive alkylation of natural amino acids
Bitan, Gal,Muller, Dan,Kasher, Ron,Gluhov, Evgenia V.,Gilon, Chaim
, p. 1501 - 1510 (2007/10/03)
A new method for the synthesis of protected Nα-(ω-Y-alkyl) amino acids (Y is a thio, amino or carboxy group) and related compounds by reductive alkylation of natural amino acids is reported. These new amino acids serve as building units for the synthesis of backbone-cyclic peptides. They are orthogonally protected at the α-amino position by butoxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc), using trimethylsilyl temporary protection, to allow for their incorporation into peptides by solid phase peptide synthesis.
Masked Lithium Bishomoenolates: Useful Intermediates in Organic Synthesis
Ramon, Diego J.,Yus, Miguel
, p. 3825 - 3831 (2007/10/02)
The lithiation of the chloro ketals 9 with lithium naphthalenide at -78 deg C led to the corresponding masked lithium bishomoenolates 4, which are stable species under these conditions and react with different electrophilic reagents (H2O, D2O, i-PrCOH, Ph
2-(3-Lithiopropyl)- and 2-(3-lithiopropyl)-2-methyl-1,3-dioxolane: New masked lithium bishomoenolates in the synthesis of bifunctionalized compounds
Ramon, Diego J.,Yus, Miguel
, p. 3763 - 3766 (2007/10/02)
2-(3-Lithiopropyl)- and 2-(3-lithiopropyl)-2-methyl-1,3-dioxolane (2) are prepaned by lithiation of the corresponding chlorinated precursors with lithium naphthalenide at -78°C. The reaction of these masked bishomoenolates with different electrophiles yie
