1335558-23-0

Basic information

• Product Name: 7-chloro-4-(4-methylphenyl)quinoline
• Synonyms: 7-chloro-4-(4-methylphenyl)quinoline
• CAS NO: 1335558-23-0
• Molecular Weight: 253.731
• Mol File: 1335558-23-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-chloro-4-(4-methylphenyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-4-(4-methylphenyl)quinoline(1335558-23-0)
• EPA Substance Registry System: 7-chloro-4-(4-methylphenyl)quinoline(1335558-23-0)

Safety Data

• Hazardous Substances Data: 1335558-23-0(Hazardous Substances Data)

Upstream product

• 98591-57-2 7-chloro-4-iodoquinoline 
• 14338-21-7 tri-(4-methylphenyl)aluminum 
• 2417-95-0 p-tolyllithium 
• 90252-89-4 p-tolylzinc(II) chloride 
• 18412-57-2 p-tolyltriethoxysilane 

Downstream Products

• 1335558-06-9 (4R)-7-chloro-4-p-tolyl-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

Copper-catalyzed cross-coupling of aryl- and heteroaryltriethoxysilanes with aryl and heteroaryl iodides and bromides

Copper(I)-catalyzed coupling of aryl- and heteroaryltriethoxysilanes with aryl and heteroaryl iodides is described. The transformation also proceeds with activated aryl bromides, but in this case it requires a stoichiometric amount of the catalyst for best product yields. The current reaction requires a P,N-based bidentate ligand for aryl-aryl coupling while it proceeds without external ligands for aryl-heteroaryl coupling to afford good product yields. The reaction protocol can also be applied to achieve biarylation of diiodoarenes in reasonable yields. Georg Thieme Verlag Stuttgart New York.

Ligand-Free Copper-Catalyzed Negishi Coupling of Alkyl-, Aryl-, and Alkynylzinc Reagents with Heteroaryl Iodides

Reported herein is an unprecedented ligand-free copper-catalyzed cross-coupling of alkyl-, aryl-, and alkynylzinc reagents with heteroaryl iodides. The reaction proceeds at room temperature for the coupling of primary, secondary, and tertiary alkylzinc reagents with heteroaryl iodides without rearrangement. An elevated temperature (100 C) is required for aryl-heteroaryl and alkynyl-heteroaryl couplings.