133604-58-7

Basic information

• Product Name: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-Hexadecaoxanonatetracontan-49-ol
• Synonyms: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-Hexadecaoxanonatetracontan-49-ol;MPEG16-OH;MPEG16-OH;m-PEG16-alcohol
• CAS NO: 133604-58-7
• Molecular Formula: C₃₃H₆₈O₁₇
• Molecular Weight: 737
• Product Categories: Miscellaneous Reagents
• Mol File: 133604-58-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 703.3±55.0 °C(Predicted)
• Appearance: /
• Density: 1.095±0.06 g/cm3(Predicted)
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-Hexadecaoxanonatetracontan-49-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-Hexadecaoxanonatetracontan-49-ol(133604-58-7)
• EPA Substance Registry System: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-Hexadecaoxanonatetracontan-49-ol(133604-58-7)

Safety Data

• Hazardous Substances Data: 133604-58-7(Hazardous Substances Data)

Usage

Description

m-PEG16-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG16-alcohol can be used in the preparation of triazolium ionic liquid catalysts which are then applied towards Stetter reaction. It is also used in the synthesis of PEG-based surfactants that show high selectivity in disrupting vesicular membranes in the presence or absence of cholesterol.

Upstream product

• 25990-96-9 octaethylene glycol monomethyl ether 
• 125274-16-0 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 112-60-7 Tetraethylene glycol 
• 1144113-16-5 2-(2-{2-[2-(2-{2-[2-(2-trityloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethanol 
• 5117-19-1 octaethylene glycol 
• 5702-16-9 2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontan-37-ol 
• 23783-42-8 tetraethylene glycol monomethyl ether 

Downstream Products

• 907577-50-8 deoxyaminohexadecaethylene glycol methyl ether 

Relevant articles and documents

Monodisperse oligoethylene glycols modified Camptothecin, 10-Hydroxycamptothecin and SN38 prodrugs

Camptothecin, which represents a class of natural products with high anticancer activity, suffers low water solubility which hampers its clinic application. To address this issue, monodisperse polyethylene glycols were employed to modify this class of natural products, including Camptothecin, 10-Hydroxycamptothecin, and SN38. Through selective modification with a series of monodisperse polyethylene glycols, 31 Camptothecin derivatives, including 9 ethers and 22 carbonates, were prepared using a macrocyclic sulfate-based strategy with high efficacy. Monodisperse polyethylene glycols modification provided the Camptothecin derivatives with high purity and fine-tunable water solubility. Through the physicochemical and biological assays, a few novel prodrugs with good solubility, cytotoxicity, and valuable drug release profile were identified as promising anticancer drug candidates.

High-purity discrete PEG-oligomer crystals allow structural insight

To great (monodisperse) lengths: An improved synthesis of purer ethylene glycol (EG) oligomers allows access to 16- and 32-mers pure enough for multiple incorporation, and also to the longest (48-mer) discrete EG oligomer yet reported. The high purity enables the first crystallizations and hence the first glimpses of secondary 310-helical PEG structures.