13362-30-6Relevant articles and documents
Synthesis method of 2-aminopyridine-4-ethyl formate intermediate
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Paragraph 0020-0064, (2019/01/23)
The invention discloses a synthesis method of a 2-aminopyridine-4-ethyl formate intermediate. The synthesis method includes the following steps of mixing 2-amino-4-methylpyridine with water, heating the mixture to 60-80 DEG C, adding a Cu-Ce-Bi-SiO2 catalyst, stirring the mixture above, then introducing O2 into the mixture, stopping introduction of O2 after a reaction is completed, conducting filtering after the temperature of the mixture drops to room temperature, and adjusting the pH of a filtrate to be 9-10; adding ethyl alcohol, conducting reduced pressure distillation to remove ethyl alcohol after a heating reflux reaction has been carried out for 1-2 hours, utilizing dichloromethane for extraction several times, combining organic phases, removing dichloromethane and obtaining 2-aminopyridine-4-ethyl formate. The synthesis method is simple in operation, mild in condition and high in product purity and product yield and generates few by-products.
Highly efficient one-pot amination of carboxylate-substituted nitrogen-containing heteroaryl chlorides via Staudinger reaction
Kandalkar, Sachin R.,Kaduskar, Rahul D.,Ramaiah, Parimi Atchuta,Barawkar, Dinesh A.,Bhuniya, Debnath,Deshpande, Anil M.
supporting information, p. 414 - 418 (2013/02/23)
An efficient one-pot method for the synthesis of tert-butyl 6-aminonicotinate (5) is described. The key transformation involves displacement of the chloro group in tert-butyl 6-chloronicotinate (2) with azide followed by a Staudinger reaction. The scope of this methodology is further extended for the synthesis of a series of carboxylate-substituted heteroaryl amines. In particular, we synthesized tert-butyl carboxylate-substituted amino-pyridine, -pyridazine, and -pyrazine. In addition to one-pot conversion, short reaction time, simplicity of operation, ease of purification, and good yields are the key advantages of this methodology.
Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents
Feng, Dennis,Fisher, Michael,Liang, Gui-Bai,Qian, Xiaoxia,Brown, Chris,Gurnett, Anne,Leavitt, Penny Sue,Liberator, Paul A.,Mathew, John,Misura, Andrew,Samaras, Samantha,Tamas, Tamas,Schmatz, Dennis M.,Wyvratt, Matthew,Biftu, Tesfaye
, p. 5978 - 5981 (2007/10/03)
Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed.
