480453-85-8Relevant academic research and scientific papers
Synthesis and biological activity of imidazopyridine anticoccidial agents: Part I
Scribner, Andrew,Dennis, Richard,Hong, Jean,Lee, Shuliang,McIntyre, Donald,Perrey, David,Feng, Dennis,Fisher, Michael,Wyvratt, Matthew,Leavitt, Penny,Liberator, Paul,Gurnett, Anne,Brown, Chris,Mathew, John,Thompson, Donald,Schmatz, Dennis,Biftu, Tesfaye
, p. 1334 - 1357 (2008/09/17)
Coccidiosis is the major cause of morbidity and mortality in the poultry industry. Protozoan parasites of the genus Eimeria invade the intestinal lining of the avian host causing tissue pathology, poor weight gain, and in some cases mortality. Resistance
Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents
Feng, Dennis,Fisher, Michael,Liang, Gui-Bai,Qian, Xiaoxia,Brown, Chris,Gurnett, Anne,Leavitt, Penny Sue,Liberator, Paul A.,Mathew, John,Misura, Andrew,Samaras, Samantha,Tamas, Tamas,Schmatz, Dennis M.,Wyvratt, Matthew,Biftu, Tesfaye
, p. 5978 - 5981 (2007/10/03)
Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed.
Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents
Biftu, Tesfaye,Feng, Dennis,Fisher, Michael,Liang, Gui-Bai,Qian, Xiaoxia,Scribner, Andrew,Dennis, Richard,Lee, Shuliang,Liberator, Paul A.,Brown, Chris,Gurnett, Anne,Leavitt, Penny S.,Thompson, Donald,Mathew, John,Misura, Andrew,Samaras, Samantha,Tamas, Tamas,Sina, Joseph F.,McNulty, Kathleen A.,McKnight, Crystal G.,Schmatz, Dennis M.,Wyvratt, Matthew
, p. 2479 - 2483 (2007/10/03)
Compounds 10a (IC50 110 pM) and 21 (IC50 40 pM) are the most potent inhibitors of Eimeria tenella cGMP-dependent protein kinase activity reported to date and are efficacious in the in vivo antiparasitic assay when administered to chi
