13369-71-6

Upstream product

• 10514-34-8 3-phenylisothiazole 
• 74-88-4 methyl iodide 
• 95514-24-2 (Z)-1-amino-1-phenyl-1-buten-3-one 
• 1008-74-8 5-methyl-3-phenylisoxazole 
• 16187-94-3 4-bromo-3-phenyl-isothiazole 
• 41009-49-8 1-phenyl-3-thiocyanato-propenone 
• 14208-30-1 3-phenyl-isothiazole-5-carbonitrile 
• 16187-90-9 β-imino-β-phenylpropionitrile 
• 21905-46-4 5-chloro-3-phenyl-isothiazole 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 13363-69-4 3-phenyl-1,2-thiazole-5-carboxylic acid 
• 16187-91-0 3-phenyl-3-iminothiopropionamide 
• 16187-93-2 4-bromo-3-phenyl-isothiazol-5-ylamine 
• 13363-44-5 5-bromo-3-phenyl-isothiazole 

Downstream Products

• 95514-26-4 (Z)-1-Phenyl-2-(3-phenyl-isothiazol-5-yl)-vinylamine 
• 95514-36-6 3-phenyl-5-phenacylisothiazole 

Relevant academic research and scientific papers

Transition Metal-Free Synthesis of Substituted Isothiazoles via Three-Component Annulation of Alkynones, Xanthate and NH4I

A protocol was described to access diverse isothiazoles with functionalization potential via transition metal-free three-component annulation of alkynones, potassium ethylxanthate (EtOCS2K) and ammonium iodide (NH4I). A sequential regioselective hydroamination/thiocarbonylation/intramolecular cyclization cascade achieved the efficient formation of consecutive C?N, C?S and N?S bonds in a one-pot process. (Figure presented.).

3, 5-disubstituted isothiazole compound and synthesis method and application thereof

The invention belongs to the technical field of organic synthesis, and discloses a 3, 5-disubstituted isothiazole compound and a synthesis method and applications thereof, the structural formula of the compound is represented by formula (II), and R1 and R2 respectively and independently represent hydrogen, a heterocyclic group, phenyl, a phenyl derivative or alkane. According to the invention, the3, 5-disubstituted isothiazole compound is synthesized by taking the acetylenic ketone compound as a raw material, heating and stirring under the condition of adding a solvent and carrying out one-pot reaction without catalysis of transition metal, and the synthesis is completed in one step without separating and purifying an intermediate in a conversion process except for a final product, so that industrial production is easy to realize, and capital and labor investment can be reduced for industrial production.

Ring Transformation Equilibrium (Bond Switch) in the 5-(2-Aminovinyl)isothiazole System via Hypervalent Sulfurane. Synthesis, Structure Determination, and Kinetic Study

Reaction of 3-aryl-5-methylisothiazoles (4) with aromatic nitriles afforded the adducts 3, 5-(2-amino-2-arylvinyl)-3-arylisothiazole derivatives, in the presence of LDA.By employing p-chlorobenzonitrile-15N, the presence of ring transformation from one is