16187-91-0

Basic information

• Product Name: 3-phenyl-3-iminothiopropionamide
• Synonyms: 3-phenyl-3-iminothiopropionamide
• CAS NO: 16187-91-0
• Molecular Weight: 178.258
• Mol File: 16187-91-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-phenyl-3-iminothiopropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-3-iminothiopropionamide(16187-91-0)
• EPA Substance Registry System: 3-phenyl-3-iminothiopropionamide(16187-91-0)

Safety Data

• Hazardous Substances Data: 16187-91-0(Hazardous Substances Data)

Upstream product

• 16187-90-9 β-imino-β-phenylpropionitrile 
• 1823-99-0 3-amino-3-phenylacrylonitrile 

Downstream Products

• 16188-24-2 3-(2,4-dichloro-phenyl)-5-methyl-isothiazole-4-carboxylic acid 
• 16188-23-1 3-(2,4-dichloro-phenyl)-5-methyl-isothiazole-4-carbonitrile 
• 16188-02-6 3-(4-chloro-phenyl)-5-methyl-isothiazole-4-carboxylic acid 
• 16188-01-5 3-(4-chloro-phenyl)-5-methyl-isothiazole-4-carbonitrile 
• 16187-97-6 5-methyl-3-phenyl-isothiazole-4-carboxylic acid amide 
• 13369-71-6 3-phenyl-5-methylisothiazole 
• 13950-63-5 5-methyl-3-phenyl-4-isothiazolecarbonitrile 
• 13950-68-0 4-cyano-3-phenylisothiazole 
• 13363-69-4 3-phenyl-1,2-thiazole-5-carboxylic acid 
• 14208-30-1 3-phenyl-isothiazole-5-carbonitrile 
• 10514-34-8 3-phenylisothiazole 
• 19762-79-9 3-(4-bromo-phenyl)-5-methyl-isothiazole-4-carbonitrile 
• 19762-89-1 5-methyl-3-(2,4,5-trichloro-phenyl)-isothiazole-4-carboxylic acid 
• 19762-78-8 5-methyl-3-(2,4,5-trichloro-phenyl)-isothiazole-4-carbonitrile 

Relevant articles and documents

Pyrimidine benzamide-based thrombopoietin receptor agonists

A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation at C-5 of the thiazole, the likely source of toxic metabolites, was removed by substitution at C-5 or by replacing the thiazole with a thiadiazole. Potency in the series was improved by modifying the substituents on the pyrimidine and/or on the thiazole or thiadiazole pendant aryl ring. In vivo examination revealed that compounds from the series are not highly bioavailable. This is attributed to low solubility and poor permeability.