16187-90-9

Basic information

• Product Name: 3-imino-3-phenylpropionitrile
• Synonyms: 3-Imino-3-phenylpropiononitrile;β-Iminobenzenepropanenitrile;β-Imino-β-phenylpropiononitrile;3-imino-3-phenylpropionitrile
• CAS NO: 16187-90-9
• Molecular Formula: C9H8N2
• Molecular Weight: 144.17322
• EINECS: 240-322-0
• Mol File: 16187-90-9.mol

Chemical Properties

• Boiling Point: 294.7°Cat760mmHg
• Flash Point: 132°C
• Appearance: /
• Density: 1.01g/cm³
• Vapor Pressure: 0.0016mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 3-imino-3-phenylpropionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-imino-3-phenylpropionitrile(16187-90-9)
• EPA Substance Registry System: 3-imino-3-phenylpropionitrile(16187-90-9)

Safety Data

• Hazardous Substances Data: 16187-90-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8N2/c10-7-6-9(11)8-4-2-1-3-5-8/h1-5,11H,6H2/b11-9+

Upstream product

• 100-47-0 benzonitrile 
• 75-05-8 acetonitrile 

Downstream Products

• 79980-01-1 2-Amino-6-phenyl-3,4,5-tricyanopyridin 
• 51803-13-5 5-cyano-2,4,6-triphenylpyrimidine 
• 13996-08-2 4,6-diphenyl-2-thioxo-1,2-dihydropyrimidine-3-carbonitrile 
• 16187-91-0 3-phenyl-3-iminothiopropionamide 
• 1190768-31-0 C₂₂H₁₈N₂O₃S 
• 1190765-90-2 2-cyano-3,5-diphenyl-4-hydroxy-6,7-dihydro-thieno[2,3-b]pyridin-6-one 
• 281195-24-2 2-amino-5-cyano-4-phenyl-thiophene-3-carboxylic acid ethyl ester 
• 16188-24-2 3-(2,4-dichloro-phenyl)-5-methyl-isothiazole-4-carboxylic acid 
• 16188-23-1 3-(2,4-dichloro-phenyl)-5-methyl-isothiazole-4-carbonitrile 
• 16188-02-6 3-(4-chloro-phenyl)-5-methyl-isothiazole-4-carboxylic acid 
• 16188-01-5 3-(4-chloro-phenyl)-5-methyl-isothiazole-4-carbonitrile 
• 16187-97-6 5-methyl-3-phenyl-isothiazole-4-carboxylic acid amide 
• 13369-71-6 3-phenyl-5-methylisothiazole 
• 13950-63-5 5-methyl-3-phenyl-4-isothiazolecarbonitrile 

Relevant articles and documents

THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS

The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).

Pyrimidine benzamide-based thrombopoietin receptor agonists

A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation at C-5 of the thiazole, the likely source of toxic metabolites, was removed by substitution at C-5 or by replacing the thiazole with a thiadiazole. Potency in the series was improved by modifying the substituents on the pyrimidine and/or on the thiazole or thiadiazole pendant aryl ring. In vivo examination revealed that compounds from the series are not highly bioavailable. This is attributed to low solubility and poor permeability.