133715-24-9

Upstream product

• 133775-35-6 (R)-(2-cyclohexen-1-yl)acetyl chloride 
• 133775-38-9 (1R, 2R)-2-(phenylthio)cyclohexyl acetate 
• 3413-44-3 (R)-2-cyclohexen-1-ol 
• 133775-37-8 (-)-(R)-cyclohex-2-enylacetic acid 
• 14447-34-8 (+)-(R)-cyclohex-2-en-1-yl acetate 
• 133715-22-7 ethyl (R)-2-cyclohexenylacetate 
• 10039-14-2 2-iodo-1-cyclohexanol 
• 14032-04-3 trans-2-phenylthiocyclohexanol 
• 144300-25-4 (1R,2R)-1-acetoxy-2-iodocyclohexane 

Downstream Products

• 133715-11-4 ((3aR,11R,11aR,11bS)-9-Benzyloxy-5-oxo-1,2,3,3a,4,5,10,11,11a,11b-decahydro-5a-aza-benzo[cd]fluoranthen-11-yl)-carbamic acid benzyl ester 
• 1027905-47-0 (3aR,11R,11aR,11bS)-9-Benzyloxy-5-oxo-1,2,3,3a,4,5,10,11,11a,11b-decahydro-5a-aza-benzo[cd]fluoranthene-11-carbonyl azide 
• 133775-36-7 <3aR-(3aα,12α,12aα,12bα)>-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydroxyisoquino<2,1,8-lma>carbazol-2(1H)-one hydrochloride 

Relevant academic research and scientific papers

Synthesis of an enantiomerically pure aminoisoquinocarbazole with antiarrhythmic activity via lipase-catalyzed enantioselective transesterification

Enantiomerically pure (R)-2-cyclohexen-1-ol 5 was prepared via lipase- catalyzed enantioselective transesterification of 2-substituted cyclohexanol, and stereospecifically converted to (-)-(2-cyclohexenyl)acetic acid 4. Enantiomerically pure aminoisoquinocarbazole 1 (RS-2135) was synthesized stereoselectively from 4, using an intramolecular Diels-Alder reaction and Curtius rearrangement.

Indolobenzoquinoline derivatives, their preparation and their use as anti-arrhythmic drugs

Optically active compounds of formula (I): in which R1 is hydrogen or alkyl; Xband Ybare hydrogen or hydroxy; and Z is -NRaRb, in which Raand Rbare hydrogen, alkyl or hydroxyalkyl,or a cyclic amino group;, and pharmaceutically acceptable salts thereof have enhanced anti-arrhythmic activity and may be prepared by a stereospecific synthesis process.