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Upstream product

• 76115-74-7 1,5-diphenyl-3-(thiophen-2-yl)pentane-1,5-dione 
• 98-03-3 thiophene-2-carbaldehyde 
• 82944-84-1 N-[(1E)-1-phenylethylidene]-P,P-diphenylphosphinic amide 
• 6028-89-3 (E)-3-thiophen-2-yl-1-p-tolylpropenone 
• 98-86-2 acetophenone 
• 98-80-6 phenylboronic acid 
• 100-52-7 benzaldehyde 
• 122712-52-1 phenyl-1 amino-1 butadiene-2,3 
• 3437-95-4 2-Iodothiophene 
• 1426150-35-7 C₁₇H₁₅N 
• 27757-85-3 2-Aminomethylthiophene 
• 21985-04-6 3-phenyl-1-(2-thienyl)-2-propyn-1-one 
• 618-36-0 rac-methylbenzylamine 
• 19433-17-1 acetophenone O-acetyloxime 

Relevant academic research and scientific papers

Wet 2,4,6-trichloro-1,3,5-triazine (TCT) as an efficient catalyst for the synthesis of 2,4,6-triarylpyridines under solvent-free conditions

An efficient one-pot synthesis of 2,4,6-triarylpyridines has been described. This involves the three-component reaction of aldehydes, ketones and ammonium acetate in the presence of a catalytic amount of wet 2,4,6-trichloro-1,3,5-triazine (TCT) under solvent-free condition at 130 °C.

Design and application of (Fe3O4)-GOTfOH based AgNPs doped starch/PEG-poly (acrylic acid) nanocomposite as the magnetic nanocatalyst and the wound dress

As a novel, recyclable nanocatalyst, (Fe3O4)-GOTfOH based Ag nanoparticles doped Starch/PEG-poly (acrylic acid) nanocomposite (Fe3O4?GOTfOH/Ag/St-PEG-AcA) was applied for one-pot synthesis

Reaction between guanidine hydroehloride and chalcones: An efficient solvent-free synthesis of 2,4,6-triarylpyridines under microwave irradiation

A series of 2,4,6-triarylpyridines have been synthesized via an efficient solvent-free reaction between guanidine hydro-chloride and chalcones under microwave irradiation in excellent yields. Copyright

Bismuth triflate catalyzed solvent-free synthesis of 2,4,6-triaryl pyridines and an unexpected selective acetalization of tetrazolo[1,5-a]- quinoline-4-carbaldehydes

Bismuth triflate has been found as a potential catalyst for an efficient and solvent-free synthesis of symmetrical 2,4,6-triarylpyridines in 86-93% yields. Moreover, catalytic reactivity of bismuth triflate toward tetrazolo[1,5-a]quinoline-4-carbaldehydes

Kr?hnke pyridines: an efficient solvent-free synthesis of 2,4,6-triarylpyridines

A simple and efficient synthesis of 2,4,6-triarylpyridines is described from a novel reaction between chalcones and ammonium acetate under solvent-free conditions in excellent yields.

Pyridine Skeleton Synthesis Using Acetonitrile as C4N1 Units and Solvent

The first [3 + 2 + 1] methodology for pyridine skeleton synthesis via cascade carbopalladation/cyclization of acetonitrile, arylboronic acids, and aldehydes was developed. This reaction proceeds via six step tandem reaction sequences involving the carbopalladation reaction of acetonitrile, a nucleophilic addition, a condensation, an intramolecular Michael addition, cyclization, and aromatization. Delightfully, both palladium acetate and supported palladium nanoparticles catalyzed this reaction with similar catalytic performance. The characterization results of the fresh and used supported palladium nanoparticle catalysts indicated that the reaction might be performed via a Pd(0)/Pd(II) catalytic cycle that began with Pd(0). Furthermore, the products showed good fluorescence characteristics. The green homogeneous/heterogenous catalytic methodologies pave a new way for constructing the pyridine skeleton.

Method for synthesizing pyridine ring structure by utilizing cascade reaction of aldehyde, arylboronic acid and acetonitrile

The invention discloses a method for synthesizing a pyridine ring structure by utilizing cascade reaction of aldehyde, arylboronic acid and acetonitrile, which comprises the following steps: dissolving a palladium catalyst, aldehyde, arylboronic acid, a l

Synthesis of triphenylpyridines: Via an oxidative cyclization reaction using Sr-doped LaCoO3 perovskite as a recyclable heterogeneous catalyst

An La0.6Sr0.4CoO3 strontium-doped lanthanum cobaltite perovskite was prepared via a gelation and calcination approach and used as a heterogeneous catalyst for the synthesis of triphenylpyridines via the cyclization reactio

Merrifield resin-supported quinone as an efficient biomimetic catalyst for metal-free, base-free, chemoselective synthesis of 2,4,6-trisubstituted pyridines

Metal-free, base-free, biomimetic and chemoselective synthesis of 2,4,6-trisubstituted pyridines was developed under mild conditions for the first time. The heterogeneous biomimetic catalyst-recoverable Merrifield resin-supported quinone-was fully characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectrometry (XPS) and energy dispersive X-ray spectroscopy (EDX). This supported quinone catalyst exhibited excellent catalytic reactivity for chemoselective synthesis of 2,4,6-trisubstituted pyridines, providing an efficient and green method for the synthesis of pyridine derivatives under mild conditions. Mechanistic investigations were conducted to gain insights into the heterogeneous biomimetic catalyst as well as the resulting transformation. The successful capture of intermediates offered direct and clear evidence for the proposed mechanism.

An efficient, green solvent-free protocol for the synthesis of 2,4,6-triarylpyridines using reusable heterogeneous activated Fuller’s earth catalyst

Abstract: A simple, efficient, and green method of preparation for the synthesis of highly substituted pyridines by multicomponent reaction of acetophenones, aldehydes, and ammonium acetate using activated Fuller’s earth as an effective and reusable heterogeneous catalyst is described. The advantages of the present protocol include simple procedure with an easy workup procedure, mild reaction conditions, and high yields of the products. The performance of this reaction under solvent-free conditions using heterogeneous catalysts, such as activated Fuller’s earth, could enhance its efficiency from an economic as well as ecological point of view. Graphical abstract: [Figure not available: see fulltext.].