1338360-74-9

Upstream product

• 1224201-15-3 (S)-3-hydroxy-6,7-dimethoxy-13,13a-dihydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline-11,14(9H,12H)-dione 
• 1224201-11-9 (S)-1-((3-hydroxy-6,7-dimethoxyphenanthren-9-yl)methyl)-5-oxopyrrolidine-2-carboxylic acid 
• 1223487-23-7 C₂₉H₂₇NO₅ 
• 1223487-21-5 (13aS)-3-(benzyloxy)-6,7-dimethoxy-13,13a-dihydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline-11,14(9H,12H)-dione 
• 1223487-18-0 (2S)-1-{[3-(benzyloxy)-6,7-dimethoxy-9-phenanthryl]methyl}-5-oxopyrrolidine-2-carboxylic acid 
• 1422707-31-0 methyl (2S)-1-{[3-(benzyloxy)-6,7-dimethoxy-9-phenanthryl]methyl}-5-oxopyrrolidine-2-carboxylate 
• 26691-62-3 [3-(benzyloxy)-6,7-dimethoxy-9-phenanthryl]methanol 
• 26847-68-7 6,7-dimethoxy-3-benzoxy-9-phenanthrenecarboxylic acid methyl ester 
• 100-39-0 benzyl bromide 
• 1449298-72-9 3-hydroxy-6,7-dimethoxy-9-phenanthrenecarboxylic acid methyl ester 

Downstream Products

• 1422707-34-3 (13aS)-3-(benzyloxy)-6,7-dimethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline 

Relevant academic research and scientific papers

A novel and practical synthesis of CAT3: A phenanthroindolizidine alkaloid with potential in treating glioblastoma

CAT3, one of the (+)-deoxytylophorinine-based phenanthroindolizidine alkaloids, is a promising therapeutic agent for the treatment of hedgehog (Hh)-driven glioblastoma and is currently being evaluated in preclinical studies. In this paper, a novel and practical synthetic route for CAT3 was firstly demonstrated with 10% overall yield in 11 steps and has been successfully validated for pilot-plant scale preparation. Investigation of the substitution at the 3-position of phenanthrene revealed that the electron-donating functionality can well preserve the S configuration. In particular, the excellent enantiomeric excess of CAT3 (≥99% ee) was achieved by introducing the strongly electron-donating tert-butyldimethylsilyl (TBS) group.

Stereospecific synthesis and biological evaluation of monodesmethyl metabolites of (+)-13a-(S)-deoxytylophorinine as potential antitumor agents

Three major monodesmethyl metabolites of (+)-13a-(S)-deoxytylophorinine were synthesized stereospecifically and their configurations at C-13a were determined. Biological assays revealed that one of the metabolites, 3-O-desmethyl-13a-(S)-deoxytylophorinine

Synthesis of phenanthroindolizidine alkaloids and evaluation of their antitumor activities and toxicities

We previously reported that phenanthroindolizidine alkaloid 3 and its derivatives had markedly potent in vitro cytotoxicity. However, they had low in vivo antitumor activities and high in vivo toxicities, which was a serious problem. To address this probl