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Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 3340-78-1 2-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 102-96-5 (2-nitroethenyl)benzene 
• 591-50-4 iodobenzene 
• 98-95-3 nitrobenzene 
• 64-04-0 phenethylamine 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Replacement of Stoichiometric DDQ with a Low Potential o-Quinone Catalyst Enabling Aerobic Dehydrogenation of Tertiary Indolines in Pharmaceutical Intermediates

A transition-metal/quinone complex, [Ru(phd)3]2+ (phd = 1,10-phenanthroline-5,6-dione), is shown to be effective for aerobic dehydrogenation of 3° indolines to the corresponding indoles. The results show how low potential quinones may be tailored to provide a catalytic alternative to stoichiometric DDQ, due to their ability to mediate efficient substrate dehydrogenation while also being compatible with facile reoxidation by O2. The utility of the method is demonstrated in the synthesis of key intermediates to pharmaceutically important molecules.

Artificial Light-Harvesting Systems Based on AIEgen-branched Rotaxane Dendrimers for Efficient Photocatalysis

Aiming at the construction of novel platform for efficient light harvesting, the precise synthesis of a new family of AIEgen-branched rotaxane dendrimers was successful realized from an AIEgen-functionalized [2]rotaxane through a controllable divergent ap

2D-MoS2 photocatalyzed cross dehydrogenative coupling reaction synchronized with hydrogen evolution reaction

The chemically exfoliated 2D-MoS2 has a mixture of 1T (metallic) and 2H (semiconducting) phases. It has shown a considerably good catalytic activity for hydrogen evolution reaction (HER), proceeding via electrochemical as well as photochemical

Cobalt(II)/ N -Hydroxyphthalimide-Catalyzed Cross-Dehydrogenative Coupling Reaction at Room Temperature under Aerobic Condition

This work reports a cobalt(II)/N-hydroxyphthalimide (NHPI)-catalyzed cross-dehydrogenative oxidative coupling of N-aryl tetrahydroisoquinolines with various pro-nucleophiles, such as indoles, nitroalkanes, and trialkylphosphites, active methylene compound

CBr4-mediated cross-dehydrogenative coupling reaction of amines

A novel CBr4-mediated dehydrogenative Povarov/aromatization tandem reaction of glycine derivatives with alkenes, leading to complex quinoline derivatives, and a CBr4-mediated dehydrogenative C?H functionalization of N-aryl tetrahydro

Cobalt-catalyzed cross-dehydrogenative coupling reaction in water by visible light

By using catalytic amount of CoCl2 with dmgH (dimethylglyoxime) as ligand to form a photosensitizer in situ, a highly selective, efficient, and environmentally benign visible light mediated cross-dehydrogenative coupling (CDC) reaction has been

A Cascade Cross-Coupling and in Situ Hydrogenation Reaction by Visible Light Catalysis

An elegant cascade cross-coupling and in situ hydrogenation reaction has been established by visible light catalysis. Combining cheap and earth-abundant eosin Y as a photosensitizer and the cobalt chloride complex, Co(dmgH)2Cl2 (dmgH=dimethylglyoximate), as a catalyst, the desired oxidative cross-coupling products and reductive hydrogenation products could be achieved in good to excellent yields without use of any external oxidants and reductants under visible light irradiation.

Cross-coupling hydrogen evolution reaction in homogeneous solution without noble metals

A highly efficient noble-metal-free homogeneous system for a cross-coupling hydrogen evolution (CCHE) reaction is developed. With cheap, earth-abundant eosin Y and molecular catalyst Co(dmgH)2Cl2, good to excellent yields for coupling reactions with a variety of isoquinolines and indole substrates and H2 have been achieved without any sacrificial oxidants. Mechanistic insights provide rich information on the effective, clean, and economic CCHE reaction.

Catalytic amounts of triarylaminium salt initiated aerobic oxidative coupling of N-aryl tetrahydroisoquinolines

A novel stable radical cation triarylaminium salt able to induce aerobic oxidative α-C-H functionalization of tertiary amines in catalytic amounts has been developed. The reaction is performed in the absence of any other additives under mild conditions an

Solvent-free cross-dehydrogenative coupling reactions under high speed ball-milling conditions applied to the synthesis of functionalized tetrahydroisoquinolines

Solvent-free reaction using a high-speed ball milling technique has been first applied to cross-dehydrogenative coupling (CDC) reactions between tetrahydroisoquinolines and three types of pronucleophiles such as nitroalkanes, alkynes, and indoles. All cou