6769-56-8Relevant articles and documents
TRICYCLIC FURAN-SUBSTITUTED PIPERIDINEDIONE COMPOUND
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, (2021/07/17)
Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND
-
, (2021/07/17)
Disclosed is a series of tricyclic substituted piperidine dione compounds, and applications thereof in the preparation of medicines for treating diseases related to CRBN protein; specifically disclosed are the derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
Three-Step One-Pot Process of 3-Methyl-5-Benzofuranol from Amine, Aldehydes, and p-Benzoquinone
Liang, Chaoming,Sun, Maolin,Shen, Xinyuan,Shan, Chao,Wang, Weijuan,Cheng, Ruihua,Ye, Jinxing
, p. 810 - 816 (2021/04/05)
3-Methyl-5-benzofuranol was prepared by a one-pot process from morpholine, propionaldehyde, and p-benzoquinone in 85-87% isolated yields. Avoiding the tedious multistep isolation and purification operations, this practical and efficient process dramatically enhanced the production efficiency as well as reduced the amount of chemical wastes of reaction. The scale-up results showed that the performance was maintained, suggesting potential large-scale applications. Furthermore, the synthesis strategy showed high efficiency for a wide range of aliphatic aldehydes and ketone derivatives.
Novel Cyclic Phenoxy Compounds and Improved Treatments for Cardiac and Cardiovascular Disease
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, (2015/02/25)
A compound of formula I, and its pharmaceutically acceptable salt or salts and physiologically hydrolysable derivatives in free form or salt form: wherein either Q1, CR6a and optionally R6b together form a cyclic moiety wh
NOVEL CYCLIC PHENOXY COMPOUNDS AND IMPROVED TREATMENTS FOR CARDIAC AND CARDIOVASCULAR DISEASE
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, (2013/08/28)
A compound of formula I, and its pharmaceutically acceptable salt or salts and physiologically hydrolysable derivatives in free form or salt form: (Formula (I)) wherein either Q1, CR6a and optionally R6b together form a cy
An efficient solid-phase synthesis of substituted benzofuran using selenium-bound resin
Zhang, Yin Jun,Wang, Yu Guang
experimental part, p. 212 - 216 (2012/07/13)
A very efficient solid-phase synthesis of substituted benzofuran using polymer-supported selenium resin is described. The advantages of the new method are good yields, high purity, straightforward operations, broad range and high diversity of products, lack of odor, and good stability of the resins. The easy work-up procedure makes the method suitable for building parallel libraries.
Natural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels-Alder reaction: Synthesis and cytotoxicity evaluation
Shen, Yu-Dong,Tian, Yuan-Xin,Bu, Xian-Zhang,Gu, Lian-Quan
experimental part, p. 3915 - 3921 (2009/12/04)
A series of new natural tanshinone-like oxoheterocyclic-fused ortho-quinone derivatives were synthesized from readily available benzofuranol and N-substituted dienes via IBX oxidation-cycloaddition-aromatization procedure. The regiospecific Diels-Alder cycloaddition reactions of N-dienes were achieved efficiently with a variety of dienophiles. It is found that the amide moiety in the molecular could be preserved or eliminated by control of the aromatization conditions. Selected oxoheterocyclic-fused ortho-quinones as well as several thioheterocyclic-fused ortho-quinones we obtained before were evaluated for their cytotoxicities on different cancer cell lines and the Structure-Activity Relationship (SAR) was discussed.
The reaction of arylacetones with boron tribromide
Dupont, Romain,Cotelle, Philippe
, p. 1651 - 1655 (2007/10/03)
Treatment of arylacetones 1 with boron tribromide gives 1,3-dimethyl-2- arylnaphthalenes 3 in fair to good yields by a tandem aldol condensation- intramolecular cyclization. This reaction is limited to the electron-rich arylacetones. In the case of methox
Depigmenting cosmetic or dermatologic composition containing a benzofuran derivative and its use in depigmentating skin
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, (2008/06/13)
A depigmenting cosmetic or dermatologic composition for use in bleaching the skin or treating pigmental spots contains in a vehicle suitable for topical application to the skin a benzofuran derivative having the formula STR1 wherein the OH function occupies position 5 or 6, R1 and R2, each independently, represent hydrogen or alkyl having 1-4 carbon atoms, n is 0 or 1, when n is 0, the C2 -C3 bond is a double bond, and when n is 1, the C2 -C3 bond is a single bond.
Dyeing composition for keratinous fibers, containing oxidation dye precursors and hydroxybenzofurane used as couplers, and dyeing process using these compositions
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, (2008/06/13)
The invention relates to the use, as coupler in a dyeing composition, of a hydroxybenzofuran of formula (I): STR1 in which R1 and R2, which are identical or different, represent a hydrogen atom or a C1 -C6 alkyl radical. When they denote an alkyl radical, R1 and R2 can occupy any position on the benzofuran ring except the positions 2 and 3 at the same time. The OH group may occupy one of the positions 4, 5, 6 or 7, in combination with one or more para type or ortho type oxidation dye precursors or mixtures thereof, for dyeing keratinous fibers and in particular human hair. The dyeing composition according to the invention makes it possible to confer on the keratinous fibers a color which is fast to light, washes, adverse weather conditions and perspiration.
