13398-38-4

Basic information

• Product Name: erythro-2-hydroxy-3-methylbutane-1,4-dioic acid
• CAS NO: 13398-38-4
• Molecular Weight: 148.116
• Mol File: 13398-38-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: erythro-2-hydroxy-3-methylbutane-1,4-dioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: erythro-2-hydroxy-3-methylbutane-1,4-dioic acid(13398-38-4)
• EPA Substance Registry System: erythro-2-hydroxy-3-methylbutane-1,4-dioic acid(13398-38-4)

Safety Data

• Hazardous Substances Data: 13398-38-4(Hazardous Substances Data)

Upstream product

• 93504-92-8 2-hydroxy-3-methylbutanedioic acid diethyl ester 
• 63921-06-2 3-methyl-2-oxo-butane-1,4-dioic acid dimethyl ester 
• 759-65-9 diethyl oxalpropionate 
• 642-92-2 D,L-threo-β-methylaspartic acid 
• 113564-09-3 (E,2R^*,3S^*)-3-hydroxy-2-methyl-4-hexenoic acid 
• 100806-42-6 (E)-(2S,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid 

Downstream Products

• 85199-56-0 2-Methyl-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester 
• 89497-03-0 (2R,3R)-2-Methyl-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester 
• 85249-22-5 (2S,3R)-2-Methyl-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester 
• 50460-80-5 dimethyl 2-hydroxy-3-methylbutane-1,4-dioate 
• 50460-80-5 dimethyl 2-hydroxy-3-methylbutane-1,4-dioate 
• 50460-80-5 (2S,3R)-2-Hydroxy-3-methylbernsteinsaeure-dimethylester 
• 5380-37-0 (2S,3R)-2-Hydroxy-3-methyl-succinic acid 
• 5380-36-9 (+)-erythro-3-Methylaepfelsaeure 
• 5380-36-9 (-)-threo-3-Methylaepfelsaeure 
• 5380-37-0 (2S,3S)-2-Hydroxy-3-methyl-succinic acid 

Relevant articles and documents

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Synthesis of erythro-2-Hydroxy-3-methylbutane-1,4-dioic Acid

Reduction of ethyl 3-methyl-2-oxobutane-1,4-dioate (3) with sodium borohydride furnishes a 6:1 mixture of ethyl erythro-2-hydroxy-3-methylbutane-1,4-dioate (8) and ethyl threo-2-hydroxy-3-methylbutane-1,4-dioate (18).Hydrolysis of this mixture with aq. hydrochloric acid gives a mixture of acids from which pure erythro-2-hydroxy-3-methylbutane-1,4-dioic acid (4) has been isolated.The stereochemistry of 4 has been establishrd by PMR and by transforming it to the anhydride, erythro-dihydro-3-acetyloxy-4-methyl-2,5-furandione (26).