5380-37-0

Basic information

• Product Name: 2-hydroxy-3-methylbutanedioate
• Synonyms: (R,S)-beta-Methylmalate; (R,S)-b-Methylmalate; 2-Hydroxy-3-methylsuccinate; butanedioic acid, 2-hydroxy-3-methyl-, ion(2-); D-erythro-3-Methylmalate; D-threo-3-Methylmalate; L-threo-3-Methylmalate
• CAS NO: 5380-37-0
• Molecular Formula: C₅H₆O₅
• Molecular Weight: 146.0992
• Mol File: 5380-37-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 295.2°C at 760 mmHg
• Flash Point: 146.6°C
• Vapor Pressure: 0.000161mmHg at 25°C
• CAS DataBase Reference: 2-hydroxy-3-methylbutanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-methylbutanedioate(5380-37-0)
• EPA Substance Registry System: 2-hydroxy-3-methylbutanedioate(5380-37-0)

Safety Data

• Hazardous Substances Data: 5380-37-0(Hazardous Substances Data)

Upstream product

• 50460-80-5 (2S,3R)-2-Hydroxy-3-methylbernsteinsaeure-dimethylester 
• 642-92-2 D,L-threo-β-methylaspartic acid 
• 63921-06-2 3-methyl-2-oxo-butane-1,4-dioic acid dimethyl ester 
• 759-65-9 diethyl oxalpropionate 
• 93504-92-8 2-hydroxy-3-methylbutanedioic acid diethyl ester 
• 113564-09-3 (E,2R^*,3S^*)-3-hydroxy-2-methyl-4-hexenoic acid 
• 874646-35-2 diisopropyl (2S,3R)-2-methyl-3-hydroxybutanedioate 
• 86562-29-0 (2R,3R)-(-)-threo-3-methylaspartic acid 
• 100806-42-6 (E)-(2S,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid 
• 874646-33-0 diisopropyl (2R,3S)-2-methyl-3-hydroxybutanedioate 
• 73840-71-8 diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate 
• 498-23-7 citraconic acid 
• 91487-33-1 dimethyl (2R,3S)-2-O-acetyl-3-methylmalate 
• 6061-13-8 (2S,3S)-3-methylaspartic acid 

Downstream Products

• 149-31-5 (2S,3S)-2-methylpentane-1,3-diol 

Relevant articles and documents

The sex pheromone of the wasp spider Argiope bruennichi

(Figure Presented) Wasp spider looking for a mate: Female wasp spiders (see picture) use trimethyl methylcitrate as a volatile cue to attract males. The experiments were performed on a sunny meadow, showing for the first time that spider traps can be used to trap spiders in the field (photo: Helen Sandford).

N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF

The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

Enantioselective Synthesis of (2R,3S)-3-Alkylmalic Acids, Competent Substrates for 3-Isopropylmalate Dehydrogenase

A series of (2R,3S)-3-alkylmalic acids was enantioselectively synthesized, in conjunction with biochemical studies on the thermostable isopropylmalate dehydrogenase derived from Thermus thermophilus, by the chirality transcription approach, using a conceptually recyclable carbohydrate template.The dianion -Wittig rearrangement of alkylated allyloxyacetic acids prepared from alkylallyl tertiary-carbinols was effective in both reactivity and stereoselectivity to afford the desired diastereomers in a high yield.The derived γ,δ-unsaturated α-hydroxycarboxylic acids were oxidatively transformed into the desired (2R,3S)-3-alkylmalic acid derivatives.