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Usage

Uses

Used in Fragrance and Flavoring Industry:
2-(2,4-Dimethoxyphenyl)ethanol is used as a fragrance and flavoring agent for its appealing and sweet scent, contributing to the creation of various perfumes, soaps, and other personal care products.
Used in Personal Care Products:
In the personal care industry, 2-(2,4-Dimethoxyphenyl)ethanol serves as a key ingredient in the formulation of perfumes, soaps, and other products, enhancing their sensory appeal through its distinctive aroma.
Used in Medicinal Research:
2-(2,4-Dimethoxyphenyl)ethanol has been studied for its potential medicinal uses, including its antioxidant and anti-inflammatory properties, indicating its possible application in the development of therapeutic agents.
Safety Considerations:
It is important to exercise caution when handling 2-(2,4-Dimethoxyphenyl)ethanol, as it can cause irritation to the skin and eyes, highlighting the need for proper safety measures during its use in various applications.

InChI:InChI=1/C10H14O3/c1-12-9-4-3-8(5-6-11)10(7-9)13-2/h3-4,7,11H,5-6H2,1-2H3

Upstream product

• 75-21-8 oxirane 
• 151-10-0 1,3-Dimethoxybenzene 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 74-85-1 ethene 
• 1057663-21-4 2-(2,4-dimethoxyphenyl)acetaldehyde 
• 40243-84-3 2,4-dimethoxystyrene 
• 1891-08-3 (2,4-dimethoxy-phenyl)-acetaldehyde-oxime 

Downstream Products

• 973-94-4 4-bromo-benzenesulfonic acid-(2,4-dimethoxy-phenethyl ester) 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 13372-46-8 2,4-dimethoxyphenethyl acetate 
• 1057663-21-4 2-(2,4-dimethoxyphenyl)acetaldehyde 
• 37567-79-6 1-(2-bromoethyl)-2,4-dimethoxybenzene 

Relevant academic research and scientific papers

Synthetic access to optically active isoflavans by using allylic substitution

A general approach to the (S)- and (R)-isoflavans was invented, and efficiency of the method was demonstrated by the synthesis of (S)-equol ((S)-3), (R)-sativan ((R)-4), and (R)-vestitol ((R)-5). The key step is the allylic substitution of (S)-6a (Ar1=2,4-(MeO)2C6H3) and (R)-6b (Ar1=2,4-(BnO)2C6H3) with copper reagents derived from CuBr·Me2S and Ar2-MgBr (7a, Ar2=4-MeOC6H4; 7b, 2,4-(MeO)2C6H3; 7c, 2-MOMO-4-MeOC6H3), furnishing anti SN2′ products (R)-8a and (S)-8b,c with 93-97% chirality transfer in 60-75% yields. The olefinic part of the products was oxidatively cleaved and the Me and Bn groups on the Ar1 moieties was then removed. Finally, phenol bromide 9a and phenol alcohols 9b,c underwent cyclization with K2CO3 and the Mitsunobu reagent to afford (S)-3 and (R)-4 and -5, respectively.

New synthetic route to (S)-(-)-equol through allylic substitution

Allylic substitution of allylic picolinate 5 with a copper reagent derived from p-MeOC6H4MgBr (6) and CuBr·Me2S produced the anti SN2′ product 7 with high regioselectivity and efficient chirality transfer. Oxidative cleavage of the olefinic function to the alcohol followed by bromination afforded bromide 16, which upon demethylation and intramolecular ether ring formation furnished (S)-(-)-equol (3).