5'-[4-(Pivaloyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy,5- fluorouridine: A membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP)

DOI: 10.1021/jm00003a012

Source and publish data:

Journal of Medicinal Chemistry p. 488 - 495 (1995)

Update date:2022-08-28

Topics:

Authors:

Farquhar

Chen Chen

Khan Khan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00003a012

5'-[4-(Pivatoyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy-5- fluorouridine (1c) was designed as a potential membrane-permeable prodrug of 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP), a putative active metabolite of the antitumor drug 5-fluorouracil

Full text of DOI:10.1021/jm00003a012

Products guided by the article

Product name:Fluorodeoxyuridylate

Cas No:134-46-3

R&D Labs maybe for 134-46-3

Chengdu Boon Stream Chemical Industry Co.,Ltd.

Contact:+86-28-83156758

Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China
Weifang Adde Economic And Trade Co.,LTD.

Contact:86-536-8885548

Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
WENZHOU M&C FOREIGN TRADE CO.,LTD.

Contact:+86-577-88862917

Address:No.8 Liming West Road,Wenzhou,zhejiang,China
PharmOrgsyn

Contact:+86-21-38228826

Address:Room 505 Building 2, No 3377 Kangxin Highway, Shanghai, Republic China
Shandong Jincheng Zhonghua Bio-pharmaceutical Co.,Ltd

Contact:+86-533-5415882

Address:Zichuan Economic Development Zone,Zibo City,Shandong Province,China

Relevant to this article

Reactivity of Inorganic α-Nucleophiles in Acyl Group Transfer Processes in Water and Surfactant Micelles: II.¹ Alkaline Hydrolysis of Ethyl 4-Nitrophenyl Ethylphosphonate in Systems Based on Dimeric Cationic Surfactants

Doi:10.1134/S1070428020010091
(2020)
Enantioselective desymmetrization of prochiral ketones via an organocatalytic deprotonation process

Doi:10.1016/j.tetasy.2013.05.011
(2013)
N₂O-Free single-pot conversion of cyclohexane to adipic acid catalysed by an iron(II) scorpionate complex

Doi:10.1039/c6gc03208g
(2017)
Microwave spectrum, structure, and dipole moment of the trans-cis isomer of ethyl vinyl ether

Doi:10.1006/jmsp.1994.1122
(1994)
Synthesis and characterization of new electron acceptor perylene diimide molecules for photovoltaic applications

Doi:10.1016/j.dyepig.2013.05.011
(2013)
Phosphotungstic acid heterogenized by assembly with pyridines for efficient catalytic conversion of fructose to methyl levulinate

Doi:10.1039/c8ra02278j
(2018)

Article Doi