5'-[4-(Pivaloyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy,5- fluorouridine: A membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP)

DOI: 10.1021/jm00003a012

Source and publish data:

Journal of Medicinal Chemistry p. 488 - 495 (1995)

Update date:2022-08-28

Topics:

Authors:

Farquhar

Chen Chen

Khan Khan

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Article abstract of DOI:10.1021/jm00003a012

5'-[4-(Pivatoyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy-5- fluorouridine (1c) was designed as a potential membrane-permeable prodrug of 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP), a putative active metabolite of the antitumor drug 5-fluorouracil

Full text of DOI:10.1021/jm00003a012

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