13401-38-2

Usage

Uses

Used in Pharmaceutical Industry:
7-Methyllumizine is used as an active pharmaceutical ingredient for its anti-inflammatory properties, helping to reduce inflammation in various conditions.
7-Methyllumizine is used as an analgesic agent for its pain-relieving capabilities, providing relief from acute and chronic pain.
7-Methyllumizine is used as an ulcerogenic agent for its ability to induce ulcers, which can be useful in research and development of treatments for ulcer-related conditions.
Used in Research and Development:
7-Methyllumizine is used as a research compound for studying its anti-inflammatory, analgesic, and ulcerogenic activities, contributing to the advancement of pharmaceutical sciences and drug discovery.

InChI:InChI=1/C7H6N4O2/c1-3-2-8-4-5(9-3)10-7(13)11-6(4)12/h2H,1H3,(H2,9,10,11,12,13)

Upstream product

• 13040-58-9 7-methylpterin 
• 42965-55-9 5,6-diaminouracil sulfate 
• 78-98-8 2-oxopropanal 
• 3240-72-0 5,6-diaminouracil 
• 42965-55-9 5,6-diamino-2,4-dihydroxypyrimidine sulfate 

Downstream Products

• 120992-57-6 5-methyl-3-oxo-3,4-dihydro-pyrazine-2-carboxylic acid 
• 6761-50-8 2-amino-6-methylpyrazine-3-carboxylic acid 
• 20721-18-0 6-methylpyrazin-2-one 
• 63876-78-8 7-styryllumazine 
• 5521-56-2 6-methylpyrazin-2-amine 
• 6298-35-7 sulfanilic acid-(6-methyl-pyrazin-2-ylamide) 

Relevant academic research and scientific papers

Evaluation of liquid chromatographic behavior of lumazinic derivatives, from α-dicarbonyl compounds, in different c18 columns: Application to wine samples using a fused-core column and fluorescence detection

Several C18 columns, packed with totally porous particles of different sizes and shell thicknesses, have been compared for simultaneous determination of α-dicarbonyl compounds, previous derivatization to lumazinic derivatives. Chromatographic conditions for the separation have been optimized for each column, and chromatographic parameters have been calculated and exhaustively compared. A core-shell C18 column provided the best results, and a HPLC method with fluorimetric detection has been proposed. The developed method has been validated in terms of linearity, precision, and sensitivity. Detection and quantification limits obtained were comprised between 0.02 and 0.30 and 0.07 and 1.0 ng mL-1, respectively, while RSD values obtained were lower than 6% and 5% in intraday and interday repeatability studies, respectively. The method has been applied to analysis of the α-dicarbonyl compounds in different types of wines. The higher levels of the total α-dicarbonyl compounds were found in sweet wines and the lower levels in white wines.

Solvent-free regioselective synthesis of 6- and 7-substituted pteridines under microwave irradiation

Reactions of 5,6-diaminouracils with α-keto aldehydes over acidic and neutral aluminum oxide under microwave irradiation gave the corresponding 6- and 7-substituted 1,2,3,4-tetrahydropteridine-2,4-diones in 63-79% yield with high regioselectivity. Pleiade

THIAZOLIUMS AS TRANSKETOLASE INHIBITORS

The present invention provides N-3'-pyridylmethyl or N-2'-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R1, R2, R3, Y, R5-R9, Ra-Rd, n and X- are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

Research on heterocyclic compounds. XXXVII. Synthesis and antiinflammatory activity of methyl-substituted imidazo[1,2-a]pyrazine derivatives

A series of methyl-substituted imidazo[1,2-a]pyrazines 8 bearing a carboxylic acid group on the imidazole ring were synthesized. The structures of new compounds were confirmed by 1H- and 13C-NMR spectral data; the correct assignment of carbon resonances was made by means of HETCOR and COLOC experiments. Antiinflammatory, analgesic and ulcerogenic activities in vivo were evaluated and compared with those of antiinflammatory imidazopyrazines (2 and 3) and indomethacin. The inhibitory action on cyclooxygenase activity was evaluated in vitro. Compounds 8 were found to be less potent than indomethacin in these assays. SARs are discussed.