134037-88-0

Basic information

• Product Name: (+)-(2R,5S,7R)-1-aza-3-oxa-2-phenyl-7-(phenylmethyl)bicyclo<3.3.0>octan-8-one
• Synonyms: (+)-(2R,5S,7R)-1-aza-3-oxa-2-phenyl-7-(phenylmethyl)bicyclo<3.3.0>octan-8-one
• CAS NO: 134037-88-0
• Molecular Weight: 293.365
• Mol File: 134037-88-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (+)-(2R,5S,7R)-1-aza-3-oxa-2-phenyl-7-(phenylmethyl)bicyclo<3.3.0>octan-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(2R,5S,7R)-1-aza-3-oxa-2-phenyl-7-(phenylmethyl)bicyclo<3.3.0>octan-8-one(134037-88-0)
• EPA Substance Registry System: (+)-(2R,5S,7R)-1-aza-3-oxa-2-phenyl-7-(phenylmethyl)bicyclo<3.3.0>octan-8-one(134037-88-0)

Safety Data

• Hazardous Substances Data: 134037-88-0(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 98-79-3 L-Pyroglutamic acid 
• 17342-08-4 (S)-Pyroglutaminol 
• 166765-32-8 (+)-(2R,5S,7S)-7-phenylmethyl-7-ethoxycarbonyl-2-phenyl-1-aza-3-oxa-bicyclo<3.3.0>octan-8-one 
• 254909-27-8 (2R,5S)-7-ethoxycarbonyl-2-phenyl-1-aza-3-oxa-lbicyclo<3.3.0>octan-8-one 
• 176243-48-4 ((+)-2R,5S,7S)-7-phenylmethyl-7-carboxyl-2-phenyl-1-aza-3-oxa-bicyclo<3.3.0>octan-8-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 150323-21-0 (-)-(2S,4R)-7-benzyl-2-hydroxymethyl-5-oxo-pyrrolidine 

Relevant articles and documents

Stereoselective alkylations of a bicyclic lactam derived from pyroglutamic acid

Improvements in the stereoselective alkylation of a bicyclic lactam derived from pyroglutamic acid are described. This methodology is used to synthesize a conformationally constrained homo-glutamic acid analog.

A CONSISE APPROACH TO FUNCTIONALISED, HOMOCHIRAL PYRROLIDINONES

Acylation of O,N-acetal 1 gives excellent yields of the C-7 substituted products 2a,b.Alkylation of 2a under mild conditions gives high yields of the exo- 3 and endo- 4 substituted products in varying ratios, depending on the alkylating agent.The unsatura

Stereoselective methylations of bicyclic lactams derived from pyroglutamic acid

Reaction of the lithium enolate of (-)7 with iodomethane provides a stereoselective synthesis of (2R,4S)-4-amino-2-methylpentanamide derivatives.