1340479-72-2Relevant academic research and scientific papers
Synthesis of a platform to access bistramides and their analogues
Commandeur, Malgorzata,Commandeur, Claude,Cossy, Janine
, p. 6018 - 6021 (2011/12/16)
The platform C14-C40, which can be used to prepare bistramide C and 39-oxobistramide K, was synthesized in 19 steps with an overall yield of 6.2%. Furthermore, the chemoselective reduction of the ketone at C-39 was performed giving an easy access to bistramides A, B, D, K, and L. Finally, the versatility of the synthesis of the C14-C40 fragment can allow the preparation of a large variety of stereoisomers to produce bistramide analogues.
