134161-19-6

Basic information

• Product Name: Benzenemethanol, a-(3-pyridinylethynyl)-
• CAS NO: 134161-19-6
• Molecular Formula: C14H11NO
• Molecular Weight: 209.247
• Mol File: 134161-19-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(3-pyridinylethynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(3-pyridinylethynyl)-(134161-19-6)
• EPA Substance Registry System: Benzenemethanol, a-(3-pyridinylethynyl)-(134161-19-6)

Safety Data

• Hazardous Substances Data: 134161-19-6(Hazardous Substances Data)

Usage

Also Known As

3-pyridinylphenylmethanol

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals, starting material for production of other organic compounds

Physical Properties

White to off-white powder, melting point of 129-133°C, boiling point of 424.9°C

Storage

Cool, dry place away from sources of ignition and incompatible materials

Hazards

Irritation to eyes and skin upon contact, harmful if ingested or inhaled in large quantities

Safety Guidelines

Handle with care and follow proper safety protocols

Upstream product

• 2510-23-8 3-Ethynylpyridine 
• 100-52-7 benzaldehyde 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 65520-08-3 3-bromopyridine hydrochloride 
• 109-89-7 diethylamine 
• 1120-90-7 3-iodopyridine 

Downstream Products

• 142354-39-0 1-phenyl-3-(pyridin-3-yl)prop-2-yn-1-one 

Relevant articles and documents

Sustainable Ligand-Free Heterogeneous Palladium-Catalyzed Sonogashira Cross-Coupling Reaction in Deep Eutectic Solvents

The commercially available and cheap Pd/C was found to promote Sonogashira couplings in the environmentally friendly choline chloride/glycerol eutectic mixture in the absence of external ligands. Under heterogeneous conditions, (hetero)aryl iodides were successfully coupled with both aromatic and aliphatic alkynes in yields ranging from 50 to 99 % within 3 h at 60 °C. The aforementioned catalytic system proved to be effective also towards electron-rich iodides, which are notoriously known to be poorly reactive in Pd-catalyzed Sonogashira coupling reactions. The eutectic mixture and the catalyst could easily and successfully be recycled up to four times with an E-factor as low as 24.4.

NaH mediated isomerisation-allylation reaction of 1,3-substituted propenols

A base mediated isomerisation-allylation protocol of 1,3-disubstituted propenols has been established. The use of diaryl and aryl-silyl substrates is reported alongside the use of substituted allyl bromides. Mechanistic experiments have also been conducted to elucidate the reaction pathway. The Royal Society of Chemistry 2013.

1-phenyl-3-aryl-2-propyne-1-one useful as calcium uptake inhibitors

This invention relates to 1-phenyl-3-aryl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.