134307-32-7

Usage

Uses

Used in Pharmaceutical Industry:
2,3,5-tri-O-benzyl-L-xylono-1,4-lactone is used as an intermediate in the synthesis of pharmaceutical compounds for its versatile chemical properties and potential biological activities. Its antimicrobial and antifungal properties make it a promising candidate for the development of new drugs to combat various infections.
Used in Agrochemical Industry:
In the agrochemical industry, 2,3,5-tri-O-benzyl-L-xylono-1,4-lactone is used as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its potential biological activities can contribute to the development of more effective and environmentally friendly agrochemicals.
Used in Material Science:
2,3,5-tri-O-benzyl-L-xylono-1,4-lactone is used as a component in the development of new materials and polymers due to its unique chemical structure and properties. Its versatility allows for the creation of materials with specific characteristics, such as improved strength, flexibility, or chemical resistance.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 2,3,5-tri-O-benzyl-L-xylono-1,4-lactone is used for the synthesis of complex organic molecules. Its reactivity and functional groups make it a valuable building block for the creation of a wide range of organic compounds, including natural products, pharmaceuticals, and specialty chemicals.
Used in Research and Development:
2,3,5-tri-O-benzyl-L-xylono-1,4-lactone is utilized in research and development for its potential applications in various industries. Its unique properties and versatility make it an attractive candidate for further exploration and innovation, leading to the discovery of new applications and advancements in various fields.

Upstream product

• 14233-65-9 1-N,2-O,3-O,5-O-tetrabenzyl-D-arabinonamide 
• 16838-89-4 2,3,5-tri-O-benzyl-L-xylofuranose 
• 14233-64-8 tri-O-benzyl-D-arabinolactone 
• 39085-59-1 trisylhydrazine 
• 89361-52-4 2,3,5-tris-O-(phenylmethyl)-β-D-ribofuranose 
• 16838-89-4 2,3,5-tri-O-benzyl-D-ribofuranose 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 5336-08-3 D-Ribono-1,4-lactone 
• 74-89-5 methylamine 
• 620946-82-9 (Z)-(2,3,5-tri-O-benzyl-D-ribofuranosylidene)amino methanesulfonate 
• 50615-49-1 2,3,4,5-tetra-O-benzyl diethyl dithioacetal D-ribose 
• 79875-99-3 (2R,3R,4R)-2,3,4,5-tetrakis(benzyloxy)pentanal 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 10257-32-6 D-ribose 

Downstream Products

• 942278-79-7 2,3,5-tri-O-benzyl-L-xylonic amide 
• 181581-98-6 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(3,5-dichloro-pyrazin-2-yl)-tetrahydro-furan-2-ol 
• 181582-01-4 (3R,4R,5R)-3,4-Bis-benzyloxy-2-(3-benzyloxy-5-chloro-pyrazin-2-yl)-5-benzyloxymethyl-tetrahydro-furan-2-ol 
• 183311-61-7 2-amino-5-(2',3,',5'-tri-O-benzyl-β-D-ribofuranosyl)pyridine 
• 190907-81-4 2-amino-3-methyl-5-(2',3,',5'-tri-O-benzyl-β-D-ribofuranosyl)pyridine 
• 377777-50-9 5-((2S,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-[2,2']bipyridinyl 
• 354113-39-6 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(3,5-dichloro-6-iodo-pyrazin-2-yl)-tetrahydro-furan-2-ol 
• 354113-40-9 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(3,5,6-tris-phenylsulfanyl-pyrazin-2-yl)-tetrahydro-furan-2-ol 
• 591751-92-7 (Z)-tert-butyl-N-[3-acetamido-4-(2,3,5-tri-O-benzyl-D-ribofuranosylidenemethyl)pyridin-2-yl] carbamate 
• 631899-56-4 (2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(2,4,5-trifluoro-phenyl)-tetrahydro-furan-2-ol 
• 631899-55-3 (2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(2,4,6-trifluoro-phenyl)-tetrahydro-furan-2-ol 

Relevant academic research and scientific papers

Benzylation of aldonolactones with benzyl trichloroacetimidate

A number of aldono-1,4-lactones have been converted to their perbenzylated derivatives by treatment with benzyl trichloroacetimidate. 2,3,6-Trideoxy-D-erythro-hexono-1,4-lactone could be benzylated in dichloromethane, but lactones containing two or more h

Weinreb Amide Approach to the Practical Synthesis of a Key Remdesivir Intermediate

Currently, remdesivir is the first and only FDA-approved antiviral drug for COVID-19 treatment. Adequate supplies of remdesivir are highly warranted to cope with this global public health crisis. Herein, we report a Weinreb amide approach for preparing the key intermediate of remdesivir in the glycosylation step where overaddition side reactions are eliminated. Starting from 2,3,5-tri-O-benzyl-d-ribonolactone, the preferred route consisting of three sequential steps (Weinreb amidation, O-TMS protection, and Grignard addition) enables a high-yield (65%) synthesis of this intermediate at a kilogram scale. In particular, the undesirable PhMgCl used in previous methods was successfully replaced by MeMgBr. This approach proved to be suitable for the scalable production of the key remdesivir intermediate.

Synthesis and Biological Evaluation of Pyrrolo[2,1-f][1,2,4]triazine C-Nucleosides with a Ribose, 2′-Deoxyribose, and 2′,3′-Dideoxyribose Sugar Moiety

The synthesis of hitherto unknown pyrrolo[2,1-f][1,2,4]triazine C-nucleosides is described. Structural variations (chlorine, bromine, iodine, and cyano groups) were introduced at position 7 of 4-aza-7,9-dideazaadenine. In addition, pyrrolo[2,1-f][1,2,4]triazine C-nucleosides bearing a 2′-deoxy-, 2′,3′-dideoxy-, and 2′,3′-dehydrodideoxyribose moiety were also prepared. Among these analogues, the pyrrolo[2,1-f][1,2,4]triazine C-ribonucleosides with either a hydrogen atom or cyano group at position 7 of the nucleobase displayed potent cytotoxic activity in a panel of various cancer cell lines.

Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents

The kinetoplastid parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are the causative agents of neglected tropical diseases with a serious burden in several parts of the world. These parasites are incapable of synthesizing purines de nov

Compound for treating viral infection and preparation method and application of compound

The invention provides a preparation for treating viral infection and pneumovirus subfamily viral infection, a method, a compound as shown in a formula (I) and a method and intermediate for synthesis of the compound as shown in the formula (I).

Compound containing guanidyl group, and preparation method and application thereof

The invention provides a preparation containing a guanidino compound and used for treating pneumoviridae virus infection, a method, a compound of a formula I, and a method and an intermediate for synthesizing the compound of the formula I.

Novel compound and application thereof

The invention relates to a novel compound and application thereof, and also relates to an application of the compound in preparation of antiviral drugs and the like. In particular, AIDS virus is present. Application of hepatitis B virus, paramyxovirus and

ISOMORPHS OF REMDESIVIR AND METHODS FOR SYNTHESIS OF SAME

A new isoform of 2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3/4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate (Remdesivir) having increased water solubility is disclosed, along with methods

Method for preparing 2, 3, 5 -tribenzyloxy - D D-ribose -1, 4 - lactone in continuous flow microchannel reactor (by machine translation)

The method disclosed by the invention has the advantages of simple operation, safety, 3 short 5 - reaction time,1 high 4 - product conversion rate, high product purity and the like 2, 3 and 5 - has the advantages of simple operation, 2 safety 3, 5 - short

Preparation method of 2, 3, 5-tribenzyloxy-D-ribose-1, 4-lactone

The invention provides a preparation method of 2, 3, 5-tribenzyloxy-D-ribose-1, 4-lactone. In the preparation method, in the oxidation step, sodium bromide/TEMPO is creatively used as a catalyst, sodium hypochlorite serves as an oxidizing agent, a large a