1344072-92-9

Upstream product

• 200341-70-4 (2E,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-enoate ethyl ester 
• 200341-72-6 (2E,4R)-5-(4-methoxybenzyloxy)-4-methyl-2-penten-1-ol 
• 136320-64-4 (2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol 
• 108865-84-5 methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 132969-71-2 methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate 
• 132969-60-9 (2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 1344072-80-5 C₂₀H₂₈O₆ 
• 1344072-55-4 tert-butyl((2,2-dimethyl-1,3-dioxolan-4-ylidene)(methoxy)methoxy)dimethylsilane 

Downstream Products

• 1344072-82-7 C₂₃H₃₄O₆ 

Relevant academic research and scientific papers

A kiyooka aldol approach for the synthesis of the C(14)-C(23) segment of the diastereomeric analog of tedanolide C

The challenging synthesis of a quaternary center within the highly oxygenated setting of tedanolide C can be performed via a Kiyooka aldol reaction. Here, the diastereomeric analog of tedanolide C with the configurations between C10 and C20 opposite compared to the proposed structure was chosen as the synthetic target. The tetra-substituted silyl ketene acetal provides the southern hemisphere of tedanolide C in useful selectivities, and the absolute configuration of the newly generated quaternary center was determined by NOE experiments of the corresponding acetonide.