1357563-67-7

Basic information

• Product Name: (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone
• Synonyms: (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone
• CAS NO: 1357563-67-7
• Molecular Weight: 338.79
• Mol File: 1357563-67-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone(1357563-67-7)
• EPA Substance Registry System: (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone(1357563-67-7)

Safety Data

• Hazardous Substances Data: 1357563-67-7(Hazardous Substances Data)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 134446-26-7 (4-bromo-phenyl)-(3-methoxy-phenyl)-methanol 
• 151239-47-3 (4-bromophenyl)-(3-methoxyphenyl)-methanone 
• 182344-13-4 (3-chloro-4-hydroxyphenyl)boronic acid 

Relevant articles and documents

Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis

E2 deficiency in elderly people has directly an effect on the skeleton and can lead to osteoporosis. As 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) catalyses the conversion between active 17β-hydroxysteroid estradiol (E2) and testosterone (T) into their less active 17-ketosteroid and has been found in bones, 17β-HSD2 inhibitor may provide a new approach in the onset of osteoporosis. Bicyclic substituted hydroxyphenylmethanone derivatives were synthesised as steroidomimetics of the substrate E2 and were evaluated for their 17β-HSD2 inhibition and their selectivity toward 17β-HSD1, catalysing the reverse reaction the conversion of estrone (E1) into E2. Highly selective compounds (11, 12, 14, 21 and 22) have been identified, the most promising one (12) showing an IC50 value in the low nanomolar range (101 nM) and a selectivity factor of 13 toward 17β-HSD1. These results make compound 12 an interesting candidate for further biological evaluation.