134447-07-7Relevant articles and documents
Molecular design of multifunctional food additives: Antioxidative antifungal agents
Nihei, Ken-Ichi,Nihei, Atsuko,Kubo, Isao
, p. 5011 - 5020 (2007/10/03)
A series of alkyl 3,4-dihydroxybenzoates (protocatechuates) was synthesized, and their fungicidal activity against Saccharomyces cerevisiae was assayed using a 2-fold serial broth dilution method. Nonyl and octyl 3,4-dihydroxybenzoate were noted to be the most effective against this yeast with the minimum fungicidal concentration of 12.5 μg/mL each. The activity was found to correlate with the hydrophobic alkyl chain length. The time-kill curve study showed that nonyl 3,4-dihydroxybenzoate was fungicidal against S. cerevisiae at any growth stage and this activity was not influenced by pH values. The fungicidal activity of alkyl 3,4-dihydroxybenzoates was noted in combination with their ability to disrupt the native membrane-associated function nonspecifically as surface-active agents (surfactants) and to inhibit the respiratory electron transport. However, the primary fungicidal activity of nonyl 3,4-dihydroxybenzoate likely comes from its ability to act as a surfactant.
The Effect of Carbonyl Containing Terminal Chains on Mesomorphic Properties in 4,4'-Disubstituted Phenylbenzoates and Thiobenzoates 8. Phenylbenzoates Containing Two Carbonyl Containing Terminal Chains
Neubert, M. E.,Keast, S. S.,Ezenyilimba, M. C.,Greer, P. B.,Jones, W. C.,et al.
, p. 47 - 68 (2007/10/02)
A variety of phenylbenzoates of the type (1) with both X and Y being the carbonyl containing chains (CH2)nCOR (n = 0 - 1), (CH2)nCO2R and (CH2)nOCOR (R = alkyl chain) in various combinations were synthesized and their mesomorphic properties studied to determine if an additive effect occurs when these chains are incorporated into the same molecule.No reliable additive effect could be found.Instead, clearing temperatures often seemed to be closer to the clearing temperature of the parent single carbonyl containing chain ester with the higher clearing temperature.An attempt was also made to improve the properties of the esters 1 with X or Y being I, F, CN or NO2 by using a carbonyl containing chain as the second substituent and assuming an additive effect.However, such an effect was also not observed in these esters.Smectic C phases were found in some of the esters with X = CN which is rare for compounds containing this substituent. - Keywords: liquid crystals, phenylbenzoates, synthesis, NMR, esters, ketones