134458-79-0

Usage

Uses

Used in Pharmaceutical Industry:
(2R,3R,4R,5S)-6-cyclohexyl-5-[(cyclohexylacetyl)amino]-3,4-dihydroxy-2-(1-methylethyl)-N-(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)carbamoyl]butylhexanamide (non-preferred name) is used as a pharmaceutical candidate for various applications due to its complex structure and potential to interact with biological targets through hydrogen bonding and hydrophobic interactions.

Upstream product

• 112190-45-1 2(R)-<5(R)-<1(S)-<(tert-butyloxycarbonyl)amino>-2-cyclohexylethyl>-2,2-dimethyl-4(R)-dioxolanyl>-3-methylbutanoic acid 
• 134527-83-6 1(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-2(S)-isopropyl-1,3-propanediol 
• 112190-42-8 3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-isopropyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone 
• 107599-99-5 (4R,5S)-(+)-3-[3-methyl-1-oxobut-1-yl]-4-methyl-5-phenyl-2-oxazolidinone 
• 117997-58-7 tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 
• 5292-21-7 Cyclohexylacetic acid 
• 146394-88-9 (2R,3R,4R,5S)-5-Amino-6-cyclohexyl-3,4-dihydroxy-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide 

Relevant academic research and scientific papers

Inhibitors of the Protease from Human Immunodeficiency Virus: Design and Modeling of a Compound Containing a Dihydroxyethylene Isostere Insert with High Binding Affinity and Effective Antiviral Activity

The peptidomimetic template and the dihydroxyethylene isostere insert that were applied successfully to the design of renin inhibitors have been extended to the related protease from human immunodeficiency virus (HIV).The present report describes the stru