134464-79-2

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 4-mercaptopiperidine-1-carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form biologically active compounds. Its unique structure and reactivity make it a versatile building block in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, tert-butyl 4-mercaptopiperidine-1-carboxylate is employed as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its reactivity and structural features allow for the creation of compounds with effective pesticidal and herbicidal properties.
Used in Organic Synthesis:
Tert-butyl 4-mercaptopiperidine-1-carboxylate is used as a valuable reagent in organic synthesis for its ability to react with various functional groups and form a wide range of compounds. Its versatility in forming different chemical entities makes it a useful building block in the synthesis of complex organic molecules.
Used in Chemical Research and Development:
In the field of chemical research and development, tert-butyl 4-mercaptopiperidine-1-carboxylate is utilized as a reagent to explore new chemical reactions and mechanisms. Its unique structure and reactivity provide insights into the development of novel synthetic routes and methodologies, contributing to the advancement of chemical science.

InChI:InChI=1/C10H19NO2S/c1-10(2,3)13-9(12)11-6-4-8(14)5-7-11/h8,14H,4-7H2,1-3H3

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 333986-94-0 4-(4-nitrophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1373131-17-9 tert-butyl 4-sulfanylidenepiperidin-1-carboxylate 
• 141699-66-3 1-tert-Butyloxycarbonyl-4-(acetylsulfanyl)piperidine 

Downstream Products

• 442199-32-8 tert-butyl 4-[(5-chloro-2-pyridyl)thio]-1-piperidinecarboxylate 
• 442198-32-5 (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide 
• 1104444-00-9 tert-butyl 4-(1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-ylthio)piperidine-1-carboxylate 
• 1129458-62-3 tert-butyl 4-(1-(4-methoxybenzyl)-4-(4-amino-2-fluorophenoxy)-1H-pyrazolo[3,4-b]pyridin-3-ylthio)piperidine-1-carboxylate 
• 1220695-36-2 tert-butyl 4-(6-(3-cyanophenyl)isoquinoline-8-ylthio)piperidine-1-calboxylate 
• 832715-08-9 4-[1-(2-fluoro-4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]-pyrimidin-4-ylsulfanyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1453186-91-8 8-isopropyl-N-((S)-1-phenylethyl)-2-(piperidin-4-ylsulfinyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine 
• 1453836-43-5 C₂₉H₃₆N₆O₂S₂ 
• 1453834-80-4 8-isopropyl-2-(piperidin-4-ylsulfinyl)-N-(2-(thiophen-2-yl)benzyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine 
• 1453834-85-9 N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-4-ylsulfonyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine 
• 1458639-55-8 tert-butyl 4-((2-chloro-6,7-dimethoxyquinazolin-4-yl)thio)piperidine-1-carboxylate 
• 1458639-57-0 4-((1-benzylpiperidin-4-yl)thio)-2-chloro-6,7-dimethoxyquinazoline 

Relevant academic research and scientific papers

BORON CONTAINING COMPOUNDS AND THEIR USES

The present disclosure contemplates novel boron-containing compounds and their uses as active agents that exhibit pesticidal activity such as antimicrobial, insecticidal, arachnicidal, and/or anti parasitic activity. An agrochemical composition containing such a compound and its use in, animal health, agriculture, or horticulture is also contemplated. A method for promoting plant performance and/or controlling, reducing, preventing, ameliorating, or inhibiting microbes, insects, arachnids, and/or parasites on or in an animal, a plant, a plant part, plant propagation material, and/or harvested fruits or vegetables is also contemplated.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

no abstract published

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

SUBSTITUTED BENZAMIDES AND THEIR USES

Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kirl.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure

PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES

Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.

SUBSTITUTED BENZAMIDES AND THEIR USES

Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use.

PYRIMIDINE DERIVATIVES AS GPCR MODTTLATORS FOR USE IN THE TREATMENT OF OBESITY AND DIABETES

The present invention relates to Pyriraidine Derivatives of formula (I), compositions comprising a Pyrimidine Derivative, and methods of using the Pyrimidine Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic di

Pleuromutilin derivatives having a purine ring. Part 2: Influence of the central spacer on the antibacterial activity against Gram-positive pathogens

Structural modification of the 4-piperidinethio moiety, as a spacer of the first pleuromutilin analogues 2A and 2B having a purine ring, led to discovery of the novel pleuromutilin derivatives 14B and 17B. These compounds with good solubility in water showed promising in vitro antibacterial activity against various Gram-positive bacteria including MRSA, PRSP, and VRE and have potent in vivo efficacy.

Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

Potent SAH analogues with constrained homocysteine units have been designed and synthesized as inhibitors of human DNMT enzymes. The five membered (2S,4S)-4-mercaptopyrrolidine-2-carboxylic acid, in 1a, was a good replacement for homocysteine, while the corresponding six-member counterpart was less active. Further optimization of 1a, changed the selectivity profile of these inhibitors. A Chloro substituent at the 2-position of 1a, compound 1d, retained potency against DNMT1, while N6 alkylation, compound 7a, conserved DNMT3b2 activity. The concomitant substitutions of 1a at both 2- and N6 positions reduced activity against both enzymes.