13450-37-8

Basic information

• Product Name: 2-(3-chlorobenzoyl)benzoic acid
• Synonyms: Benzoic acid, 2-(3-chlorobenzoyl)-; 2-(3-Chlorobenzoyl)benzoic acid
• CAS NO: 13450-37-8
• Molecular Formula: C₁₄H₉ClO₃
• Molecular Weight: 260.6725
• EINECS: 236-606-9
• Mol File: 13450-37-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 474.8°C at 760 mmHg
• Flash Point: 241°C
• Density: 1.357g/cm³
• Vapor Pressure: 8E-10mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 2-(3-chlorobenzoyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chlorobenzoyl)benzoic acid(13450-37-8)
• EPA Substance Registry System: 2-(3-chlorobenzoyl)benzoic acid(13450-37-8)

Safety Data

• Hazardous Substances Data: 13450-37-8(Hazardous Substances Data)

Usage

General Description

2-(3-chlorobenzoyl)benzoic acid, also known as 3-chloro-2-benzoylbenzoic acid, is a compound with the molecular formula C14H9ClO3. It is a white to off-white powder that is sparingly soluble in water. This chemical is used in the synthesis of organic and pharmaceutical compounds, as well as a coupling agent in the production of adducts and polymers. Its primary industrial applications include its use as an intermediate in the manufacturing of dyes, pigments, and pharmaceuticals. It is important to handle this compound with care, as it may cause irritation to the skin, eyes, and respiratory system, and should be used in a well-ventilated area with appropriate personal protective equipment.

Upstream product

• 85-52-9 2-Benzoylbenzoic acid 
• 6268-18-4 2-(3-amino-benzoyl)-benzoic acid 
• 85-44-9 phthalic anhydride 
• 108-37-2 1-bromo-3-chlorobenzene 
• 2159-38-8 2-(3'-nitrobenzoyl)benzoic acid 
• 26767-07-7 2-(3-chlorophenyl)-2-oxoacetic acid 
• 65-85-0 benzoic acid 

Downstream Products

• 13450-06-1 9b-(3-chloro-phenyl)-1,2,3,9b-tetrahydro-imidazo[2,1-a]isoindol-5-one 
• 42156-76-3 2-(4-chloro-benzoyl)-benzoyl chloride 
• 20942-28-3 methyl 2-(3-chlorobenzyl)benzoate 
• 20942-32-9 <2-(3-Chlorbenzyl)phenyl>essigsaeure 
• 20942-31-8 <2-(3-Chlorbenzyl)phenyl>acetonitril 
• 20942-29-4 (2-(3-chlorobenzyl)phenyl)methanol 
• 20942-30-7 C₁₄H₁₂BrCl 
• 137537-57-6 4-(3-Chloro-phenyl)-2-isopropyl-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid amide 
• 137537-46-3 2-(3-Chloro-benzoyl)-N-cyanomethyl-N-isopropyl-benzamide 
• 137537-33-8 4-(3-Chloro-phenyl)-2-isopropyl-1-oxo-1,2-dihydro-isoquinoline-3-carbonitrile 
• 143390-71-0 9b-(3-chloro-phenyl)-2,3-dihydro-9bH-thiazolo[2,3-a]isoindol-5-one 
• 4889-76-3 3-chlorobenzylbenzoic acid 
• 131-09-9 2-chloroanthracene-9,10-dione 

Relevant articles and documents

The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1

Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants, young children and adults. Compound 1a (9b-(4-chlorophenyl)-1-(4-fluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one) was identified as an inhibitor of A and B strains of RSV targeting the fusion glycoprotein. SAR was developed by systematic exploration of the phenyl (R1) and benzoyl (R2) groups. Furthermore, introduction of a nitrogen at the 8-position of the tricyclic core resulted in active analogues with improved properties (aqueous solubility, protein binding and log D) and excellent rat pharmacokinetics (e.g., rat oral bioavailability of 89% for compound 17).

Decarboxylative C-H arylation of benzoic acids under radical conditions

A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K2S 2O8 to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.