2159-38-8

Usage

Structure

A benzene ring with a nitro group attached to the third position and a benzoyl group attached to the second position.

Derivative

Benzoic acid

Usage

Organic synthesis, building block for pharmaceuticals and materials, production of dyes, pigments, and other organic compounds

Hazardous nature

Considered a hazardous substance, requires careful handling and disposal

Upstream product

• 85-52-9 2-Benzoylbenzoic acid 
• 20643-69-0 3-(m-nitrophenyl)-3-methoxyphthalide 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 85-44-9 phthalic anhydride 
• 98-95-3 nitrobenzene 

Downstream Products

• 32017-74-6 2-(3-nitro-benzoyl)-benzoic acid methyl ester 
• 149816-87-5 9b-(3-nitrophenyl)-2,3-dihydrothiazolo<2,3-a>isoindol-5(9bH)-one 
• 632340-55-7 2-(3'-nitrobenzyl)benzoic acid 
• 605-32-3 2-hydroxy-9,10-anthraquinone 
• 82-45-1 1-amino-9,10-anthracenedione 
• 634602-13-4 2-(3-hydroxy-benzoyl)-benzoic acid 
• 3882-50-6 2-amino-3'-nitro-benzophenone 
• 5497-16-5 9b-(3-hydroxyphenyl)-2,3-dihydrothiazolo<2,3-a>isoindol-5(9bH)-one 
• 149816-86-4 9b-(3-aminophenyl)-2,3-dihydrothiazolo<2,3-a>isoindol-5(9bH)-one 
• 632340-69-3 2-[3'-nitro(bromobenzyl)]benzoic acid 
• 854166-16-8 2-(3-nitro-benzoyl)-benzoyl azide 
• 16063-03-9 2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one 
• 6268-18-4 2-(3-amino-benzoyl)-benzoic acid 
• 13450-37-8 o-(3-chloro-benzoyl)-benzoic acid 

Relevant academic research and scientific papers

Hydrolysis of 3-(m-Nitrophenyl)-3-methoxyphthalide

The hydrolysis of 3-(m-nitrophenyl)-3-methoxyphthalide to o-(m-nitrobenzoyl)benzoic acid is general-base catalyzed in acetate buffers at pH 4-6.The rate expression is: kobsd= 1.60*10-6+6.38*10-4+>+2.08*10

Efficient synthesis of isobenzofuran-1(3H)-ones (Phthalides) and selected biological evaluations

The studies presented here deal with the convenient and efficient one-step conversion of o-alkylbenzoic acids into their corresponding isobenzofuran-1 (3H)-ones (phthalides) using NaBrO3/NaHSO3 in a two-phase system. A range of o-alkylbenzoic acids was used with the object of getting a variety of phthalide derivatives as multipurpose biologically active compounds. Seventeen phthalides have been synthesized and tested for cytotoxicity, antibacterial and antifungal activities. Some of these compounds showed promising cytotoxic effects against Artemia salina. Compounds 4j-4p were highly active against Gram-negative and Gram-positive bacteria among all tested compounds. In the fungicidal assay, the compounds showed a broad spectrum of activity against six fungi. All compounds were characterized via elemental analysis, UV, IR, mass and-NMR spectroscopy. ECV · Editio Cantor Verlag.

An alternative method for the synthesis of γ-lactones by using cesium fluoride-celite/acetonitrile combination

A variety of 2-(1-bromoalkyl) benzoic acids 4 undergo intramolecular nucleophilic substitution reaction when treated with a CsF-Celite as solid base in acetonitrile under reflux condition to give the corresponding cyclized phthalides in moderate to very good yield. These 2-(1-bromoalkyl) benzoic acids 4 are formed by the α-bromination of 2-alkylbenzoic acids 3 using N-bromosuccinimide and a catalytic amount of α,α′ -azoisobutyronitrile in carbon tetrachloride under reflux.

Process for the production of nitro derivatives of aromatic compounds

Nitroderivates of aromatic compounds which are difficult to nitrate, can readily be obtained by nitration providing that the aromatic compound is treated with nitric acid or another nitrating agent in the presence of aliphatic or cycloaliphatic hydrocarbons monosubstituted or polysubstituted by halogen, the nitro group or an alkyl sulphonyl group, and the nitro derivative formed subsequently isolated.