134517-57-0

Basic information

• Product Name: 2,4-DICHLORO-6-FLUOROQUINAZOLINE
• Synonyms: 2,4-Dichloro-6-fluoroquinazolin;4-dichloro-6-fluoroquinazoline
• CAS NO: 134517-57-0
• Molecular Formula: C₈H₃Cl₂FN₂
• Molecular Weight: 217.03
• Mol File: 134517-57-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 201.7 °C at 760 mmHg
• Flash Point: 75.8 °C
• Appearance: /
• Density: 1.571 g/cm³
• Vapor Pressure: 0.43mmHg at 25°C
• Refractive Index: 1.644
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.09±0.30(Predicted)
• CAS DataBase Reference: 2,4-DICHLORO-6-FLUOROQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-6-FLUOROQUINAZOLINE(134517-57-0)
• EPA Substance Registry System: 2,4-DICHLORO-6-FLUOROQUINAZOLINE(134517-57-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 134517-57-0(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-6-fluoroquinazoline is a chemical compound with the molecular formula C9H4Cl2FN3. It is a white crystalline solid and is primarily used as an intermediate in the synthesis of pharmaceuticals. The compound has a molecular weight of 228.05 g/mol and a melting point of 217-220 degrees Celsius. 2,4-Dichloro-6-fluoroquinazoline is also used in the production of dyes and pigments. It is important to handle this chemical with care, as it may be harmful if ingested or inhaled and can cause irritation to the skin and eyes.

InChI:InChI=1/C8H3Cl2FN2/c9-7-5-3-4(11)1-2-6(5)12-8(10)13-7/h1-3H

Upstream product

• 88145-90-8 6-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 
• 61272-77-3 2-cyano-4-fluoroaniline 
• 319-64-2 5-fluoro-β-(hydroxylimino)isatin 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 319-24-4 2-amino-5-fluoro-benzoic acid methyl ester 
• 446-08-2 2-amino-5-fluorobenzoic acid 

Downstream Products

• 769158-12-5 2-chloro-6-fluoroquinazolin-4(3H)-one 
• 1292802-51-7 C₂₀H₁₇FN₄O₂ 
• 1292802-52-8 C₂₉H₃₅FN₆O 
• 1292802-53-9 C₂₈H₃₃FN₆O 
• 1292802-54-0 C₂₇H₂₉Cl₂FN₆O 
• 769158-13-6 2-((2-chloro-6-fluoro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile 

Relevant articles and documents

One-pot cascade ring enlargement of isatin-3-oximes to 2,4-dichloroquinazolines mediated by bis(trichloromethyl)carbonate and triarylphosphine oxide

An efficient and convenient one-pot cascade synthesis of 2,4-dichloroquinazolines directly from isatin-3-oximes with the addition of bis(trichloromethyl)carbonate and triarylphosphine oxide was developed, leading to substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a range of functional groups. Thus, the method represents a convenient and practical strategy for the synthesis of substituted 2,4-dichloroquinazolines.

AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: (I) wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

SUBSTITUTED QUINAZOLINE COMPOUNDS AND PREPARATION AND USES THEREOF

The present invention relates quinazolinone compounds of Formula (I), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses； wherein the compounds or pharmaceutical compositions disclosed herein can be used for antagonizing the orexin receptor. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing neurological and psychiatric disorders and diseases of the central nervous system in mammals, especially in humans.