88145-90-8 Usage
Uses
Used in Medicinal Chemistry:
2,4-dihydroxyl-6-fluoroquinazoline is used as a pharmaceutical precursor for the development of biologically active molecules, leveraging its unique structural features to enhance pharmacological activities.
Used in Drug Development:
In the pharmaceutical industry, 2,4-dihydroxyl-6-fluoroquinazoline is used as a key intermediate in the synthesis of new drugs, potentially contributing to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Organic Synthesis:
2,4-dihydroxyl-6-fluoroquinazoline is utilized as a building block in organic synthesis, enabling the creation of more complex organic compounds and functional materials with diverse applications across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 88145-90-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,1,4 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 88145-90:
(7*8)+(6*8)+(5*1)+(4*4)+(3*5)+(2*9)+(1*0)=158
158 % 10 = 8
So 88145-90-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H5FN2O2/c9-4-1-2-6-5(3-4)7(12)11-8(13)10-6/h1-3H,(H2,10,11,12,13)
88145-90-8Relevant academic research and scientific papers
Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors
Thorat, Dhanaji Achyutrao,Doddareddy, Munikumar Reddy,Seo, Seon Hee,Hong, Tae-Joon,Cho, Yong Seo,Hahn, Ji-Sook,Pae, Ae Nim
scheme or table, p. 1593 - 1597 (2011/05/05)
Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly.
