1345824-01-2

Upstream product

• 100-42-5 styrene 
• 3695-00-9 di(4-tosyl)amine 
• 136918-14-4 phthalimide 
• 1345824-06-7 acetoxy((4-methyl)-N-tosylbenzenesulfonamidyl)iodosobenzene 
• 1414869-28-5 acetoxy(4-methyl-N-tosylebenzenesulfonamide)iodo-4-methylbenzene 
• 1414869-29-6 methoxy(N-tosyl-4-methylbenzene-1-sulfonamidyl)-4-methyliodosobenzene 
• 1414869-21-8 μ-oxo-bis[(4-methyl)-N-tosylbenzenesulfonamidyl(phenyl)iodine] 
• 1414869-22-9 μ-oxo-bis[bis-(4-methyl-N-tosylbenzenesulfonamide)(4-nitrophenyl)iodine(III)] 
• 1414869-23-0 μ-oxobis [N-tosyl-4-methylbenzene-1-sulfonamidyl(p-trifluoromethylphenyl)iodine(III)] 
• 1414869-25-2 bis[(4-methyl)-N-tosylbenzenesulfonamidyl]iodosobenzene 
• 1414869-24-1 μ-oxo-bis[bis-(4-methyl-N-tosylbenzenesulfonamide)(biphenyl-2,2'-yl)-bis-iodine(III)] 

Relevant academic research and scientific papers

Palladium-catalyzed vicinal difunctionalization of internal alkenes: Diastereoselective synthesis of diamines

Internal affairs: The first general palladium-catalyzed intermolecular diamination of internal alkenes employs different nitrogen sources, which add to the alkene in a regio- and diastereoselective fashion. The resulting diamination products can be converted directly into a known ligand motif. Copyright

A Practical Aryliodine(I/III) Catalysis for the Vicinal Diamination of Styrenes

2,6-Disubstituted iodoarenes bearing amide-functionalized side arms are reported as new structures in redox-active iodine(I/III) catalysis. In combination with bis-sulfonimides as nitrogen sources and 3-chloroperbenzoic acid (mCPBA) as benign terminal oxi

Rhodium-Catalyzed Alkene Difunctionalization with Nitrenes

The RhII-catalyzed oxyamination and diamination of alkenes generate 1,2-amino alcohols and 1,2-diamines, respectively, in good to excellent yields and with complete regiocontrol. In the case of diamination, the intramolecular reaction provides

Substitution Effects of Hypervalent Iodine(III) Reagents in the Diamination of Styrene

The influence of electronic parameters on the reaction performance of hypervalent iodine(III) reagents in the vicinal diamination of styrene has been investigated. It demonstrates the influence of the relative electron density on the aryl substituent of t

Oxidative diamination promoted by dinuclear iodine(III) reagents

New dinuclear iodine(III) reagents for the intermolecular diamination of alkenes are reported. These are accessible through protolytic aminolysis events, which generate defined imido-iodine(III) groups.

Defined hypervalent iodine(III) reagents incorporating transferable nitrogen groups: Nucleophilic amination through electrophilic activation

Only I and N: Hypervalent iodine(III) reagents with two reactive I-N single bonds have been isolated for the first time. Their solid-state and solution structures provide evidence for enhanced electrophilicity at iodine and nucleophilic character of the imine. As a result, improved reactivity in amination reactions and unprecedented nitrogen-transfer reactions under metal-free conditions are realized. Copyright

NOVEL IODINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND USE THEREOF AS AMINATION AGENTS

The iodine compounds of the present invention corresponds to those of formula (I), wherein R1, R1' and X have several meanings. These iodine compounds gives rise to the amination of several substrates without the need of catalysts, especially metal catalysts, and confer to the amination reaction the further advantage of being performed under mild conditions, which is of interest for industrial-scale production of nitrogenated compounds with pharmaceutical, biological or medicinal applications. Therefore, the iodine compounds of the invention are useful as amination agents. The invention also discloses several processes for the preparation of the iodine compounds of formula (I).

Iodine(III)-promoted intermolecular diamination of alkenes

A rapid and productive vicinal diamination of alkenes takes place in the presence of a hypervalent iodine(III) reagent and bissulfonimides as nitrogen sources. A total of more than 60 examples are presented. The reaction is characterized by its robustness and its wide substrate scope: it proceeds selectively with both terminal and internal alkenes and tolerates a range of functional groups.

Enantioselective metal-free diamination of styrenes

Metal-free and asymmetric: The first enantioselective diamination of styrenes simply requires a chiral hypervalent iodine(III) reagent as an oxidant and bismesylimide as a nitrogen source (see scheme, Ms=methanesulfonyl). The reaction proceeds under mild conditions and with high enantiomeric excess.