1346253-82-4

Usage

Chemical compound

3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazolidin-2-one

Class

Oxazolidinone

Components

Boron-containing group: Attached to a phenyl ring
Oxazolidinone functional group

Properties

Versatile building block in organic synthesis
Potential for forming carbon-carbon and carbon-heteroatom bonds
Specific reactivity and stereochemical control imparted by the oxazolidinone moiety

Applications

Organic synthesis
Medicinal chemistry
Material science

Specific content

Boron-containing group: 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl
Attached to: Phenyl ring
Oxazolidinone moiety: Present
Potential applications: Formation of carbon-carbon and carbon-heteroatom bonds
Value: Diverse synthetic applications and potential for creating new organic compounds

Upstream product

• 22036-26-6 3-(4-aminophenyl)-1,3-oxazolidin-2-one 
• 73183-34-3 bis(pinacol)diborane 
• 124-38-9 carbon dioxide 
• 106-93-4 ethylene dibromide 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 

Downstream Products

• 1386859-80-8 ethyl 2-amino-7-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3H-1-benzazepine-4-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED URACILS AND USE THEREOF

The present application relates to novel substituted uracil derivatives of formula (I), to a method for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases.

A One-Pot Synthesis of N-Aryl-2-Oxazolidinones and Cyclic Urethanes by the Lewis Base Catalyzed Fixation of Carbon Dioxide into Anilines and Bromoalkanes

The multicomponent assembly of pharmaceutically relevant N-aryl-oxazolidinones through the direct insertion of carbon dioxide into readily available anilines and dibromoalkanes is described. The addition of catalytic amounts of an organosuperbase such as Barton's base enables this transformation to proceed with high yields and exquisite substrate functional-group tolerance under ambient CO2pressure and mild temperature. This report also provides the first proof-of-principle for the single-operation synthesis of elusive seven-membered ring cyclic urethanes.