1346574-53-5

Basic information

• Product Name: 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-
• Synonyms: 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-;6-bromo-1-sec-butyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide
• CAS NO: 1346574-53-5
• Molecular Formula: C₂₂H₂₆BrN₃O₂
• Molecular Weight: 444.36474
• Mol File: 1346574-53-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-(1346574-53-5)
• EPA Substance Registry System: 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-(1346574-53-5)

Safety Data

• Hazardous Substances Data: 1346574-53-5(Hazardous Substances Data)

Usage

Molecular Structure

1H-Indole-4-carboxamide,6-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)has a complex molecular structure that includes an indole ring, a bromo group, and various methyl and oxo functional groups.

Indole Ring

The indole ring is a key structural component of this compound, which is a tricyclic aromatic system consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing ring.

Bromo Group

The presence of a bromo group (Br) in the 6-position of the indole ring confers a high level of reactivity and selectivity to the molecule, which can be useful in various synthetic transformations.

Oxo Functional Group

The oxo group (C=O) is present in the 2-position of the pyridine ring, which can act as an electron-withdrawing group, affecting the reactivity and polarity of the molecule.

1-Methylpropyl Substituent

A 1-methylpropyl (CH3CH2CH2CH3) group is attached to the nitrogen atom of the indole ring, which can influence the compound's steric properties and solubility.

Potential Applications

1H-Indole-4-carboxamide,6-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)may have potential applications in the fields of organic synthesis, pharmaceuticals, or agrochemicals due to its unique structure and functional groups.

Further Investigation

The specific properties and potential uses of this compound would need to be further investigated through experimental studies and testing to determine its suitability for various applications.

Upstream product

• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 1346576-39-3 methyl 6-bromo-1-(sec-butyl)-3-methyl-1H-indole-4-carboxylate 
• 1346576-38-2 methyl 6-bromo-1-(sec-butyl)-3-formyl-1H-indole-4-carboxylate 
• 1346576-37-1 methyl 6-bromo-1-(sec-butyl)-1H-indole-4-carboxylate 
• 107650-20-4 5-bromo-2-methyl-3-nitro-benzoic acid 
• 107650-22-6 methyl 6-bromo-1-isopropyl-3-methyl-1H-indole-4-carboxylate 
• 771579-27-2 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one 
• 1346575-54-9 6-bromo-1-(sec-butyl)-3-methyl-1H-indole-4-carboxylic acid 

Downstream Products

• 1346574-55-7 (R)-6-bromo-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide 
• 1346574-54-6 (S)-6-bromo-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide 
• 1346574-57-9 GSK-126 
• 1346574-60-4 6-{3-[(dimethylamino)methyl]phenyl}-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-1H-indole-4-carboxamide 
• 1346574-61-5 6-{3-[(dimethylamino)methyl]phenyl}-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-[(1R)-1-methylpropyl]-1H-indole-4-carboxamide 
• 1346574-59-1 6-{3-[(dimethylamino)methyl]phenyl}-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)-1H-indole-4-carboxamide 

Relevant articles and documents

METHOD OF TREATMENT

The present invention relates to a method of treating T cell mediated inflammatory immune diseases or T cell mediated hypersensitivity diseases, which comprises administering to a human in need thereof an effective amount of a compound which inhibits EZH2 and/or EZH1, or a pharmaceutically acceptable salt thereof.