13466-29-0

Usage

Uses

Used in Coordination Chemistry:
N-(benzylideneamino)methanamine is used as a ligand for the formation of coordination compounds. Its ability to chelate with metal ions allows for the creation of stable complexes that are valuable in various chemical and catalytic processes.
Used in Organic Synthesis:
In the realm of organic synthesis, N-(benzylideneamino)methanamine is employed as a building block for the preparation of a diverse array of molecules. Its reactivity and structural attributes make it a useful component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Applications:
N-(benzylideneamino)methanamine is used as a potential active pharmaceutical ingredient due to its demonstrated biological activity. Its exploration in drug discovery is driven by its capacity to interact with biological targets, offering potential therapeutic benefits in various medical conditions.
Used in Chemical Research:
As a compound of interest in chemical research, N-(benzylideneamino)methanamine is utilized in studies aimed at understanding its properties, reactivity, and potential applications. This research contributes to the broader knowledge base of organic chemistry and may lead to new methodologies or applications in the field.

InChI:InChI=1/C8H10N2/c1-9-10-7-8-5-3-2-4-6-8/h2-7,9H,1H3/b10-7+

Upstream product

• 100-52-7 benzaldehyde 
• 60-34-4 methylhydrazine 
• 7732-18-5 water 
• 120-46-7 1,3-diphenylpropanedione 
• 93-91-4 1-phenylbutan-1,3-dione 
• 1202447-73-1 ethyl 2-benzoyl-3-oxo-2,3-dihydrobenzo[b]selenophene-2-carboxylate 
• 1202447-74-2 2,2-dibenzoylbenzo[b]selenophen-3(2H)-one 
• 1202447-75-3 2-benzoyl-2-nitrobenzo[b]selenophen-3(2H)-one 
• 1202447-76-4 diethyl 2-benzoyl-3-oxo-2,3-dihydrobenzo[b]selenophen-2-ylphosphonate 
• 102-96-5 (2-nitroethenyl)benzene 
• 932-90-1 Benzaldoxime 
• 622-29-7 N-Benzylidenemethylamine 

Downstream Products

• 21303-67-3 3-(benzylidene-methyl-hydrazino)-2-cyano-acrylic acid ethyl ester 
• 33830-53-4 3,3,3-Trifluoro-2-trifluoromethyl-thiopropionic acid N-methyl-N'-[1-phenyl-meth-(Z)-ylidene]-hydrazide 
• 21907-04-0 N-Chloracetyl-N-methyl-N'-benzylidenhydrazin 
• 39182-12-2 (E)-3-{N-Methyl-N'-[1-phenyl-meth-(E)-ylidene]-hydrazino}-acrylic acid methyl ester 
• 13915-68-9 benzaldehyde 2-chloroformyl-2-methylhydrazone 
• 65889-71-6 3-(N²-benzylidene-N¹-methylhydrazino)-2-cyano-3-methylthioacrylonitrile 
• 102276-32-4 N,1-Dimethyl-2-(phenylmethylen)-hydrazinsulfonamid 
• 125299-82-3 1-methyl-5-(1,2,3,4,5-penta-O-acetyl-D-galacto-pentitol-1-yl)-3-phenylpyrazole 
• 95642-85-6 C₁₀H₁₃N₃ 
• 143780-55-6 C₁₂H₁₇N₃ 
• 95642-87-8 Benzoic Acid 1-Benzylidene-2-methylhydrazidoimine 
• 95643-06-4 C₁₅H₁₅N₃*HI 
• 143780-57-8 C₁₆H₁₇N₃ 
• 136515-48-5 1,4-dimethyl-3,6-diphenyl-1,2,3,4-tetrahydro-s-tetrazine 

Relevant academic research and scientific papers

Insertion and fragmentation of 2-ferrocenylmethylidene-1, 3-diketones upon their reactions with N-methylhydrazine

(Chemical Equation Presented) Reactions of 2-ferrocenylmethylidene-1,3- diketones (1a-c) with methylhydrazine afford mainly insertion products (～40-58%), viz., 1-(N′-acyl-N′-methylhydrazino)-1-ferrocenyl-2- acylethanes (7a-d), together with lesser amounts

One-Pot Reaction to Obtain N,N′-Disubstituted Guanidines of Pyrazolo[4,3- e ][1,2,4]triazolo[1,5- c ]pyrimidine Scaffold as Human A3 Adenosine Receptor Antagonists

In this paper we describe an extension SAR study of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine nucleus as A3AR antagonist. Our initial aim was to replace the phenylcarbamoyl moiety at the 5 position of PTP nucleus with a thiourea functiona

One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines

A scalable, one-pot, enantioselective catalytic synthesis of 2-pyrazolines from beta-substituted enones and hydrazines is described. Pivoting on a two-stage catalytic Michael addition/condensation strategy, the use of an aldehyde to generate a suitable hydrazone derivative of the hydrazine was found to be key for curtailing background reactivity and tuning the catalyst-controlled enantioselectivity. The new synthetic method is easy to perform, uses a new and readily prepared cinchona-derived bifunctional catalyst, is broad in scope, and tolerates a range of functionalities with high enantioselectivity (up to >99:1 e.r.). The significant scalability of this methodology was demonstrated with the synthesis of more than 80 grams of a pyrazoline product with 89 % catalyst recovery.

PROCESS FOR THE MANUFACTURE OF IMINIUM COMPOUNDS AND THEIR APPLICATION IN THE MANUFACTURE OF PYRAZOLE DERIVATIVES

Process for the manufacture of iminium compounds and their application in the manufacture of pyrazole derivatives The present invention concerns processes for the manufacture of iminium compounds and their application in the manufacture of pyrazole derivatives, in particular in processes for the manufacture of pharmaceutically or agrochemically active compounds.

SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS

The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)

Mechanistic Studies on the Michael Addition of Amines and Hydrazines to Nitrostyrenes: Nitroalkane Elimination via a Retro-aza-Henry-Type Process

In this article we report on the mechanistic studies of the Michael addition of amines and hydrazines to nitrostyrenes. Under the present conditions, the corresponding N-alkyl/aryl substituted benzyl imines and N-methyl/phenyl substituted benzyl hydrazones were observed via a retro-aza-Henry-type process. By combining organic synthesis and characterization experiments with computational chemistry calculations, we reveal that this reaction proceeds via a protic solvent-mediated mechanism. Experiments in deuterated methanol CD3OD reveal the synthesis and isolation of the corresponding deuterated intermediated Michael adduct, results that support the proposed slovent-mediated pathway. From the synthetic point of view, the reaction occurs under mild, noncatalytic conditions and can be used as a useful platform to yield the biologically important N-methyl pyrazoles in a one-pot manner, simple starting with the corresponding nitrostyrenes and the methylhydrazine.

Preparation of 5-Aryl-2-Alkyltetrazoles with Aromatic Aldehydes, Alkylhydrazine, Di-tert-butyl Azodicarboxylate, and [Bis(trifluoroacetoxy)iodo]benzene

A variety of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles were directly prepared in good to moderate yields by the reaction of aromatic aldehydes with methylhydrazine and benzylhydrazine, followed by treatment with di-tert-butyl azodicarboxylate and [bis(trifluoroacetoxy)iodo]benzene in a mixture of dichloromethane and 2,2,2-trifluoroethanol at room temperature. The present method is a novel one-pot preparation of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles through a [2N + 2N] combination under transition metal-free and mild conditions.

Radical Addition of Hydrazones by α-Bromo Ketones to Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis

A novel efficient tandem reaction of hydrazones and α-bromo ketones is reported for the preparation of 1,3,5-trisubstituted pyrazoles by visible light catalysis. In this system, the monosubstituted hydrazones show wonderful reaction activity with alkyl radicals, generated from α-bromo ketones. A radical addition followed by intramolecular cyclization affords the important pyrazole skeleton in good to excellent yields. This efficient strategy under mild conditions with wide group tolerance provides a potential approach to the 1,3,5-trisubstituted pyrazoles.

Synthesis of o -(dimethylamino)aryl ketones, acridones, acridinium salts, and 1 H -indazoles by the reaction of hydrazones and arynes

A novel, efficient route to biologically and pharmaceutically important o-(dimethylamino)aryl ketones, acridones, acridinium salts, and 1H-indazoles has been developed starting from readily available hydrazones of aldehydes and o-(trimethylsilyl)aryl triflates. The reaction proceeds through arynes under mild conditions, tolerates a wide range of functional groups, and provides the final products in good to excellent yields.

Method for preparing 1,3,4-substituted pyrazol compounds

The invention provides an Ethernet bridge or router comprising a network fabric adapted to provide interconnectivity to a plurality of Ethernet ports, each of the Ethernet ports being adapted to receive and/or transmit Ethernet frames, and wherein the Ethernet bridge or router further comprises an encapsulator connected to receive Ethernet Protocol Data Units from the Ethernet ports, wherein the encapsulator is operable to generate a Fabric Protocol Data Unit from a received Ethernet Protocol Data Unit, the Fabric Protocol Data Unit comprising a header portion, and a payload portion which comprises the Ethernet Protocol Data Unit concerned, and wherein the encapsulator is operable to transform Ethernet destination address information from the Ethernet Protocol Data Unit into a routing definition for the network fabric, and to include this routing definition in the header portion of the Fabric Protocol Data Unit. Also provided is a method of data delivery across a network.