116344-32-2

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid, 1-methyl-5-phenyl-, ethyl ester
• Synonyms: 1-methyl-4-carboethoxy-5-phenyl-pyrazole
• CAS NO: 116344-32-2
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.266
• Mol File: 116344-32-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid, 1-methyl-5-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid, 1-methyl-5-phenyl-, ethyl ester(116344-32-2)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid, 1-methyl-5-phenyl-, ethyl ester(116344-32-2)

Safety Data

• Hazardous Substances Data: 116344-32-2(Hazardous Substances Data)

Usage

Structure

1H-Pyrazole-4-carboxylic acid, 1-methyl-5-phenyl-, ethyl ester

Type

Chemical compound

Usage

Organic synthesis and pharmaceutical research

Known for

Potential biological and pharmacological activities, anti-inflammatory and analgesic properties

Possible applications

Development of new drugs and therapeutic agents

Safety precautions

Handle and use with proper safety measures to avoid health risks

Upstream product

• 623-47-2 propynoic acid ethyl ester 
• 1353100-91-0 ethyl 3-bromo-1H-pyrazole-4-carboxylate 
• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 
• 105486-72-4 5-bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 98-80-6 phenylboronic acid 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 17903-41-2 phenyl(trimethylsilyl)methyl bromide 
• 34592-98-8 N-methyl-α-(trimethylsilyl)benzylamine 
• 770-09-2 benzyltrimethylsilane 
• 60-34-4 methylhydrazine 
• 256658-41-0 N-methyl-N-nitroso-α-(trimethylsilyl)benzylamine 
• 13466-29-0 1-benzylidene-2-methylhydrazine 
• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 

Downstream Products

• 105994-75-0 1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

New reactivity of nitropyrimidinone: Ring transformation and N-C transfer reactions

Nitropyrimidinone 1 revealed new reactivity upon treatment with active methylene compounds 2 under basic conditions. The N1-C2-C3-C4 moiety of 1 combined with two carbon units of 2 affording polyfunctionalized pyridones 4, which was hitherto unknown ring transformation. On the other hand, the N1-C2 moiety of 1 was transferred to the methylene group of 2 giving functionalized enamines 3. It was also possible to modify the amino group in 3a by reactions with primary amines. Enamines 3 reacted with hydrazines, and leading to functionalized pyrazoles 7 quantitatively. The ratios of regioisomeric pyrazoles 7/8 were moderately controlled by use of sterically hindered enamines 3h, 3k and 31. Furthermore, enamine 3a was readily converted to 1,4-diazepines 9 having a functional group at the 6-position.

A CONVENIENT SYNTHESIS OF 2-PYRAZOLINES AND PYRAZOLES FROM ALDEHYDE HYDRAZONES AND ETHYL PROPIOLATE

Aldehyde methylhydrazones (3) reacted with ethyl propiolate in the presence of acetic acid affording 4-ethoxycarbonyl-1-methyl-2-pyrazolines (4) in 13-44percent yields.Easily 4 was dehydrated to the corresponding pyrazoles (6) by treatment with H2O2 in the presence of FeCl2.